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Search for the Function of NWC, Third Gene Within RAG Locus: Generation and Characterization of NWC-Deficient Mice

NWC is a third gene within recombination activating gene (RAG) locus, which unlike RAG genes is ubiquitously expressed and encodes a unique protein containing three strongly evolutionarily conserved domains not found in any other known protein. To get insight into its function we identified several...

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Detalles Bibliográficos
Autores principales: Kasztura, Monika, Sniezewski, Lukasz, Laszkiewicz, Agnieszka, Majkowski, Michal, Kobak, Kamil, Peczek, Karolina, Janik, Sylwia, Kapusniak, Violetta, Miazek, Arkadiusz, Cebrat, Malgorzata, Kisielow, Pawel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4939155/
https://www.ncbi.nlm.nih.gov/pubmed/26703212
http://dx.doi.org/10.1007/s00005-015-0379-1
Descripción
Sumario:NWC is a third gene within recombination activating gene (RAG) locus, which unlike RAG genes is ubiquitously expressed and encodes a unique protein containing three strongly evolutionarily conserved domains not found in any other known protein. To get insight into its function we identified several proteins co-immunoprecipitating with NWC protein and generated new NWC-deficient mice. Here, we present evidence that unlike many other ubiquitously expressed evolutionarily conserved proteins, functional inactivation of NWC does not cause any gross developmental, physiological or reproductive abnormalities and that under physiological conditions NWC may be involved in assembling and functioning of cilia, cell surface organelles found on nearly every eukaryotic cell.