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Identification of Plants That Inhibit Lipid Droplet Formation in Liver Cells: Rubus suavissimus Leaf Extract Protects Mice from High-Fat Diet-Induced Fatty Liver by Directly Affecting Liver Cells
Fatty liver disease is a condition in which abnormally large numbers of lipid droplets accumulate in liver cells. Fatty liver disease induces inflammation under conditions of oxidative stress and may result in cancer. To identify plants that protect against fatty liver disease, we examined the inhib...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4939186/ https://www.ncbi.nlm.nih.gov/pubmed/27429636 http://dx.doi.org/10.1155/2016/4282758 |
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author | Takahashi, Tomohiro Sugawara, Wataru Takiguchi, Yuya Takizawa, Kento Nakabayashi, Ami Nakamura, Mitsuo Nagano-Ito, Michiyo Ichikawa, Shinichi |
author_facet | Takahashi, Tomohiro Sugawara, Wataru Takiguchi, Yuya Takizawa, Kento Nakabayashi, Ami Nakamura, Mitsuo Nagano-Ito, Michiyo Ichikawa, Shinichi |
author_sort | Takahashi, Tomohiro |
collection | PubMed |
description | Fatty liver disease is a condition in which abnormally large numbers of lipid droplets accumulate in liver cells. Fatty liver disease induces inflammation under conditions of oxidative stress and may result in cancer. To identify plants that protect against fatty liver disease, we examined the inhibitory effects of plant extracts on lipid droplet formation in mouse hepatoma cells. A screen of 98 water extracts of plants revealed 4 extracts with inhibitory effects. One of these extracts, Rubus suavissimus S. Lee (Tien-cha or Chinese sweet tea) leaf extract, which showed strong inhibitory effects, was tested in a mouse fatty liver model. In these mouse experiments, intake of the plant extract significantly protected mice against fatty liver disease without affecting body weight gain. Our results suggest that RSE directly affects liver cells and protects them from fatty liver disease. |
format | Online Article Text |
id | pubmed-4939186 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-49391862016-07-17 Identification of Plants That Inhibit Lipid Droplet Formation in Liver Cells: Rubus suavissimus Leaf Extract Protects Mice from High-Fat Diet-Induced Fatty Liver by Directly Affecting Liver Cells Takahashi, Tomohiro Sugawara, Wataru Takiguchi, Yuya Takizawa, Kento Nakabayashi, Ami Nakamura, Mitsuo Nagano-Ito, Michiyo Ichikawa, Shinichi Evid Based Complement Alternat Med Research Article Fatty liver disease is a condition in which abnormally large numbers of lipid droplets accumulate in liver cells. Fatty liver disease induces inflammation under conditions of oxidative stress and may result in cancer. To identify plants that protect against fatty liver disease, we examined the inhibitory effects of plant extracts on lipid droplet formation in mouse hepatoma cells. A screen of 98 water extracts of plants revealed 4 extracts with inhibitory effects. One of these extracts, Rubus suavissimus S. Lee (Tien-cha or Chinese sweet tea) leaf extract, which showed strong inhibitory effects, was tested in a mouse fatty liver model. In these mouse experiments, intake of the plant extract significantly protected mice against fatty liver disease without affecting body weight gain. Our results suggest that RSE directly affects liver cells and protects them from fatty liver disease. Hindawi Publishing Corporation 2016 2016-06-26 /pmc/articles/PMC4939186/ /pubmed/27429636 http://dx.doi.org/10.1155/2016/4282758 Text en Copyright © 2016 Tomohiro Takahashi et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Takahashi, Tomohiro Sugawara, Wataru Takiguchi, Yuya Takizawa, Kento Nakabayashi, Ami Nakamura, Mitsuo Nagano-Ito, Michiyo Ichikawa, Shinichi Identification of Plants That Inhibit Lipid Droplet Formation in Liver Cells: Rubus suavissimus Leaf Extract Protects Mice from High-Fat Diet-Induced Fatty Liver by Directly Affecting Liver Cells |
title | Identification of Plants That Inhibit Lipid Droplet Formation in Liver Cells: Rubus suavissimus Leaf Extract Protects Mice from High-Fat Diet-Induced Fatty Liver by Directly Affecting Liver Cells |
title_full | Identification of Plants That Inhibit Lipid Droplet Formation in Liver Cells: Rubus suavissimus Leaf Extract Protects Mice from High-Fat Diet-Induced Fatty Liver by Directly Affecting Liver Cells |
title_fullStr | Identification of Plants That Inhibit Lipid Droplet Formation in Liver Cells: Rubus suavissimus Leaf Extract Protects Mice from High-Fat Diet-Induced Fatty Liver by Directly Affecting Liver Cells |
title_full_unstemmed | Identification of Plants That Inhibit Lipid Droplet Formation in Liver Cells: Rubus suavissimus Leaf Extract Protects Mice from High-Fat Diet-Induced Fatty Liver by Directly Affecting Liver Cells |
title_short | Identification of Plants That Inhibit Lipid Droplet Formation in Liver Cells: Rubus suavissimus Leaf Extract Protects Mice from High-Fat Diet-Induced Fatty Liver by Directly Affecting Liver Cells |
title_sort | identification of plants that inhibit lipid droplet formation in liver cells: rubus suavissimus leaf extract protects mice from high-fat diet-induced fatty liver by directly affecting liver cells |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4939186/ https://www.ncbi.nlm.nih.gov/pubmed/27429636 http://dx.doi.org/10.1155/2016/4282758 |
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