Histiocytic Sarcoma Associated with Coombs Negative Acute Hemolytic Anemia: A Rare Presentation

Histiocytic sarcoma (HS) rarely involves extranodal sites, such as the spleen. We report a unique pediatric case of massive splenomegaly and refractory Coombs negative hemolytic anemia (CNHA) secondary to HS. The CNHA resolved completely after an emergent splenectomy. Next generation sequencing (NGS...

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Autores principales: Batra, Sandeep, Martin, Stephen C., Nassiri, Mehdi, Qureshi, Amna, Markel, Troy A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2016
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4939191/
https://www.ncbi.nlm.nih.gov/pubmed/27429816
http://dx.doi.org/10.1155/2016/3179147
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author Batra, Sandeep
Martin, Stephen C.
Nassiri, Mehdi
Qureshi, Amna
Markel, Troy A.
author_facet Batra, Sandeep
Martin, Stephen C.
Nassiri, Mehdi
Qureshi, Amna
Markel, Troy A.
author_sort Batra, Sandeep
collection PubMed
description Histiocytic sarcoma (HS) rarely involves extranodal sites, such as the spleen. We report a unique pediatric case of massive splenomegaly and refractory Coombs negative hemolytic anemia (CNHA) secondary to HS. The CNHA resolved completely after an emergent splenectomy. Next generation sequencing (NGS) revealed novel ASXL1, PTPN11, KIT, and TP53 mutations, unmasking a clonal heterogeneity within the same neoplasm.
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spelling pubmed-49391912016-07-17 Histiocytic Sarcoma Associated with Coombs Negative Acute Hemolytic Anemia: A Rare Presentation Batra, Sandeep Martin, Stephen C. Nassiri, Mehdi Qureshi, Amna Markel, Troy A. Case Rep Oncol Med Case Report Histiocytic sarcoma (HS) rarely involves extranodal sites, such as the spleen. We report a unique pediatric case of massive splenomegaly and refractory Coombs negative hemolytic anemia (CNHA) secondary to HS. The CNHA resolved completely after an emergent splenectomy. Next generation sequencing (NGS) revealed novel ASXL1, PTPN11, KIT, and TP53 mutations, unmasking a clonal heterogeneity within the same neoplasm. Hindawi Publishing Corporation 2016 2016-06-26 /pmc/articles/PMC4939191/ /pubmed/27429816 http://dx.doi.org/10.1155/2016/3179147 Text en Copyright © 2016 Sandeep Batra et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Batra, Sandeep
Martin, Stephen C.
Nassiri, Mehdi
Qureshi, Amna
Markel, Troy A.
Histiocytic Sarcoma Associated with Coombs Negative Acute Hemolytic Anemia: A Rare Presentation
title Histiocytic Sarcoma Associated with Coombs Negative Acute Hemolytic Anemia: A Rare Presentation
title_full Histiocytic Sarcoma Associated with Coombs Negative Acute Hemolytic Anemia: A Rare Presentation
title_fullStr Histiocytic Sarcoma Associated with Coombs Negative Acute Hemolytic Anemia: A Rare Presentation
title_full_unstemmed Histiocytic Sarcoma Associated with Coombs Negative Acute Hemolytic Anemia: A Rare Presentation
title_short Histiocytic Sarcoma Associated with Coombs Negative Acute Hemolytic Anemia: A Rare Presentation
title_sort histiocytic sarcoma associated with coombs negative acute hemolytic anemia: a rare presentation
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4939191/
https://www.ncbi.nlm.nih.gov/pubmed/27429816
http://dx.doi.org/10.1155/2016/3179147
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