Radioprotective Effect of Grape Seed Proanthocyanidins In Vitro and In Vivo

We have demonstrated that grape seed proanthocyanidins (GSPs) could effectively scavenge hydroxyl radical (•OH) in a dose-dependent manner. Since most of the ionizing radiation- (IR-) induced injuries were caused by •OH, this study was to investigate whether GSPs would mitigate IR-induced injuries i...

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Autores principales: Huang, Yijuan, Zhao, Hainan, Cao, Kun, Sun, Ding, Yang, Yanyong, Liu, Cong, Cui, Jianguo, Cheng, Ying, Li, Bailong, Cai, Jianming, Gao, Fu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4939198/
https://www.ncbi.nlm.nih.gov/pubmed/27429710
http://dx.doi.org/10.1155/2016/5706751
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author Huang, Yijuan
Zhao, Hainan
Cao, Kun
Sun, Ding
Yang, Yanyong
Liu, Cong
Cui, Jianguo
Cheng, Ying
Li, Bailong
Cai, Jianming
Gao, Fu
author_facet Huang, Yijuan
Zhao, Hainan
Cao, Kun
Sun, Ding
Yang, Yanyong
Liu, Cong
Cui, Jianguo
Cheng, Ying
Li, Bailong
Cai, Jianming
Gao, Fu
author_sort Huang, Yijuan
collection PubMed
description We have demonstrated that grape seed proanthocyanidins (GSPs) could effectively scavenge hydroxyl radical (•OH) in a dose-dependent manner. Since most of the ionizing radiation- (IR-) induced injuries were caused by •OH, this study was to investigate whether GSPs would mitigate IR-induced injuries in vitro and in vivo. We demonstrated that GSPs could significantly reduce IR-induced DNA strand breaks (DSBs) and apoptosis of human lymphocyte AHH-1 cells. This study also showed that GSPs could protect white blood cells (WBC) from IR-induced injuries, speed up the weight of mice back, and decrease plasma malondialdehyde (MDA), thus improving the survival rates of mice after ionizing radiation. It is suggested that GSPs have a potential as an effective and safe radioprotective agent.
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spelling pubmed-49391982016-07-17 Radioprotective Effect of Grape Seed Proanthocyanidins In Vitro and In Vivo Huang, Yijuan Zhao, Hainan Cao, Kun Sun, Ding Yang, Yanyong Liu, Cong Cui, Jianguo Cheng, Ying Li, Bailong Cai, Jianming Gao, Fu Oxid Med Cell Longev Research Article We have demonstrated that grape seed proanthocyanidins (GSPs) could effectively scavenge hydroxyl radical (•OH) in a dose-dependent manner. Since most of the ionizing radiation- (IR-) induced injuries were caused by •OH, this study was to investigate whether GSPs would mitigate IR-induced injuries in vitro and in vivo. We demonstrated that GSPs could significantly reduce IR-induced DNA strand breaks (DSBs) and apoptosis of human lymphocyte AHH-1 cells. This study also showed that GSPs could protect white blood cells (WBC) from IR-induced injuries, speed up the weight of mice back, and decrease plasma malondialdehyde (MDA), thus improving the survival rates of mice after ionizing radiation. It is suggested that GSPs have a potential as an effective and safe radioprotective agent. Hindawi Publishing Corporation 2016 2016-06-26 /pmc/articles/PMC4939198/ /pubmed/27429710 http://dx.doi.org/10.1155/2016/5706751 Text en Copyright © 2016 Yijuan Huang et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Huang, Yijuan
Zhao, Hainan
Cao, Kun
Sun, Ding
Yang, Yanyong
Liu, Cong
Cui, Jianguo
Cheng, Ying
Li, Bailong
Cai, Jianming
Gao, Fu
Radioprotective Effect of Grape Seed Proanthocyanidins In Vitro and In Vivo
title Radioprotective Effect of Grape Seed Proanthocyanidins In Vitro and In Vivo
title_full Radioprotective Effect of Grape Seed Proanthocyanidins In Vitro and In Vivo
title_fullStr Radioprotective Effect of Grape Seed Proanthocyanidins In Vitro and In Vivo
title_full_unstemmed Radioprotective Effect of Grape Seed Proanthocyanidins In Vitro and In Vivo
title_short Radioprotective Effect of Grape Seed Proanthocyanidins In Vitro and In Vivo
title_sort radioprotective effect of grape seed proanthocyanidins in vitro and in vivo
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4939198/
https://www.ncbi.nlm.nih.gov/pubmed/27429710
http://dx.doi.org/10.1155/2016/5706751
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