Cargando…

Tau-Centric Targets and Drugs in Clinical Development for the Treatment of Alzheimer's Disease

The failure of several Phase II/III clinical trials in Alzheimer's disease (AD) with drugs targeting β-amyloid accumulation in the brain fuelled an increasing interest in alternative treatments against tau pathology, including approaches targeting tau phosphatases/kinases, active and passive im...

Descripción completa

Detalles Bibliográficos
Autores principales:	Panza, Francesco, Solfrizzi, Vincenzo, Seripa, Davide, Imbimbo, Bruno P., Lozupone, Madia, Santamato, Andrea, Zecca, Chiara, Barulli, Maria Rosaria, Bellomo, Antonello, Pilotto, Alberto, Daniele, Antonio, Greco, Antonio, Logroscino, Giancarlo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi Publishing Corporation 2016
Materias:	Review Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4939203/ https://www.ncbi.nlm.nih.gov/pubmed/27429978 http://dx.doi.org/10.1155/2016/3245935

Ejemplares similares

Age-related hearing impairment and frailty in Alzheimer's disease: interconnected associations and mechanisms
por: Panza, Francesco, et al.
Publicado: (2015)

Nutrition, frailty, and Alzheimer's disease
por: Panza, Francesco, et al.
Publicado: (2014)

Different Cognitive Frailty Models and Health- and Cognitive-related Outcomes in Older Age: From Epidemiology to Prevention
por: Panza, Francesco, et al.
Publicado: (2018)

Are apolipoprotein E fragments a promising new therapeutic target for Alzheimer’s disease?
por: Vecchio, Filomena Lo, et al.
Publicado: (2022)

CYP2D6 genotypes in revolving door patients with bipolar disorders: A case series
por: Seripa, Davide, et al.
Publicado: (2018)

Can a Positive Allosteric Modulation of GABAergic Receptors Improve Motor Symptoms in Patients with Parkinson's Disease? The Potential Role of Zolpidem in the Treatment of Parkinson's Disease
por: Daniele, Antonio, et al.
Publicado: (2016)

Sensorial frailty: age-related hearing loss and the risk of cognitive impairment and dementia in later life
por: Panza, Francesco, et al.
Publicado: (2018)

A New Presenilin 1 (Psen1) Mutation (p.Cys263Trp) as a Cause of Both Early and Late-Onset Alzheimer’s Disease in a Large Italian Family
por: Tortelli, Rosanna, et al.
Publicado: (2021)

The Relationship between Oral Health-Related Quality of Life and Body Mass Index in an Older Population from Southern Italy: The Salus in Apulia Study
por: Dibello, Vittorio, et al.
Publicado: (2023)

Neuropsychiatric Symptoms, Endophenotypes, and Syndromes in Late-Onset Alzheimer's Disease: Focus on APOE Gene
por: Panza, Francesco, et al.
Publicado: (2011)

Liver fibrosis score, physical frailty, and the risk of dementia in older adults: The Italian Longitudinal Study on Aging
por: Solfrizzi, Vincenzo, et al.
Publicado: (2020)

Exploring the Association of Burning Mouth Syndrome with Depressive and Anxiety Disorders in Middle-Aged and Older Adults: A Systematic Review
por: Dibello, Vittorio, et al.
Publicado: (2023)

Postural and Balance Disorders in Patients with Parkinson's Disease: A Prospective Open-Label Feasibility Study with Two Months of Action Observation Treatment
por: Santamato, Andrea, et al.
Publicado: (2015)

The Age-Related Central Auditory Processing Disorder: Silent Impairment of the Cognitive Ear
por: Sardone, Rodolfo, et al.
Publicado: (2019)

Are NSAIDs Useful to Treat Alzheimer's Disease or Mild Cognitive Impairment?
por: Imbimbo, Bruno P., et al.
Publicado: (2010)

Sarcopenia screening in elderly with Alzheimer’s disease: performances of the SARC-F-3 and MSRA-5 questionnaires
por: Bramato, Giulia, et al.
Publicado: (2022)

Impact of apolipoprotein E isoforms on sporadic Alzheimer’s disease: beyond the role of amyloid beta
por: Lozupone, Madia, et al.
Publicado: (2023)

Hydroxytryptamine transporter gene-linked polymorphic region (5HTTLPR) is associated with delusions in Alzheimer’s disease
por: D’Onofrio, Grazia, et al.
Publicado: (2019)

Social Frailty in the COVID-19 Pandemic Era
por: Lozupone, Madia, et al.
Publicado: (2020)

Oral frailty and neurodegeneration in Alzheimer’s disease
por: Dibello, Vittorio, et al.
Publicado: (2021)

Plasma Inflammatory Cytokines Are Elevated in ALS
por: Tortelli, Rosanna, et al.
Publicado: (2020)

Relationship between Inflammatory Food Consumption and Age-Related Hearing Loss in a Prospective Observational Cohort: Results from the Salus in Apulia Study
por: Sardone, Rodolfo, et al.
Publicado: (2020)

Polyunsaturated Fatty Acid and S-Adenosylmethionine Supplementation in Predementia Syndromes and Alzheimer's Disease: A Review
por: Panza, Francesco, et al.
Publicado: (2009)

The Role of Age on Beta-Amyloid(1–42) Plasma Levels in Healthy Subjects
por: Zecca, Chiara, et al.
Publicado: (2021)

Frontal assessment battery for detecting executive dysfunction in amyotrophic lateral sclerosis without dementia: a retrospective observational study
por: Barulli, Maria Rosaria, et al.
Publicado: (2015)

FOXO1 locus and acetylcholinesterase inhibitors in elderly patients with Alzheimer’s disease
por: Paroni, Giulia, et al.
Publicado: (2014)

Physical activity, interleukin-6 change, and gait speed
por: Panza, Francesco, et al.
Publicado: (2023)

Genetic Profile, Environmental Exposure, and Their Interaction in Parkinson's Disease
por: Polito, Letizia, et al.
Publicado: (2016)

Brain Structural Covariance Networks in Behavioral Variant of Frontotemporal Dementia
por: Nigro, Salvatore, et al.
Publicado: (2021)

Temporomandibular Disorders as a Risk Factor for Suicidal Behavior: A Systematic Review
por: Dibello, Vittorio, et al.
Publicado: (2022)

The Italian Version of the Test Your Memory (TYM-I): A Tool to Detect Mild Cognitive Impairment in the Clinical Setting
por: Barulli, Maria Rosaria, et al.
Publicado: (2021)

Ultrasound-Guided Injection of Botulinum Toxin Type A for Piriformis Muscle Syndrome: A Case Report and Review of the Literature
por: Santamato, Andrea, et al.
Publicado: (2015)

Role of inflammatory markers in the diagnosis of vascular contributions to cognitive impairment and dementia: a systematic review and meta-analysis
por: Custodero, Carlo, et al.
Publicado: (2022)

Risk Factors of Suicidal Behaviour in old age
por: Lozupone, M., et al.
Publicado: (2022)

Motoric Cognitive Risk Syndrome, Subtypes and 8-Year All-Cause Mortality in Aging Phenotypes: The Salus in Apulia Study
por: Bortone, Ilaria, et al.
Publicado: (2022)

Early pathological gambling in co-occurrence with semantic variant primary progressive aphasia: a case report
por: Battista, Petronilla, et al.
Publicado: (2019)

Dietary Habits and Nutrient Intakes Are Associated to Age-Related Central Auditory Processing Disorder in a Cohort From Southern Italy
por: Lampignano, Luisa, et al.
Publicado: (2021)

Neurocognitive Disorders and Dehydration in Older Patients: Clinical Experience Supports the Hydromolecular Hypothesis of Dementia
por: Lauriola, Michele, et al.
Publicado: (2018)

Dietary Fatty Acids and Predementia Syndromes
por: Solfrizzi, Vincenzo, et al.
Publicado: (2009)

Liver Fibrosis and 8-Year All-Cause Mortality Trajectories in the Aging Cohort of the Salus in Apulia Study
por: Zupo, Roberta, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_9l51jg4fmvt9qadaeku5jivc11