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Analgesic Neural Circuits Are Activated by Electroacupuncture at Two Sets of Acupoints
To investigate analgesic neural circuits activated by electroacupuncture (EA) at different sets of acupoints in the brain, goats were stimulated by EA at set of Baihui-Santai acupoints or set of Housanli acupoints for 30 min. The pain threshold was measured using the potassium iontophoresis method....
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4939346/ https://www.ncbi.nlm.nih.gov/pubmed/27429635 http://dx.doi.org/10.1155/2016/3840202 |
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author | Hu, Man-Li Qiu, Zheng-Ying Hu, Kuang Ding, Ming-Xing |
author_facet | Hu, Man-Li Qiu, Zheng-Ying Hu, Kuang Ding, Ming-Xing |
author_sort | Hu, Man-Li |
collection | PubMed |
description | To investigate analgesic neural circuits activated by electroacupuncture (EA) at different sets of acupoints in the brain, goats were stimulated by EA at set of Baihui-Santai acupoints or set of Housanli acupoints for 30 min. The pain threshold was measured using the potassium iontophoresis method. The levels of c-Fos were determined with Streptavidin-Biotin Complex immunohistochemistry. The results showed pain threshold induced by EA at set of Baihui-Santai acupoints was 44.74% ± 4.56% higher than that by EA at set of Housanli acupoints (32.64% ± 5.04%). Compared with blank control, EA at two sets of acupoints increased c-Fos expression in the medial septal nucleus (MSN), the arcuate nucleus (ARC), the nucleus amygdala basalis (AB), the lateral habenula nucleus (HL), the ventrolateral periaqueductal grey (vlPAG), the locus coeruleus (LC), the nucleus raphe magnus (NRM), the pituitary gland, and spinal cord dorsal horn (SDH). Compared with EA at set of Housanli points, EA at set of Baihui-Santai points induced increased c-Fos expression in AB but decrease in MSN, the paraventricular nucleus of the hypothalamus, HL, and SDH. It suggests that ARC-PAG-NRM/LC-SDH and the hypothalamus-pituitary may be the common activated neural pathways taking part in EA-induced analgesia at the two sets of acupoints. |
format | Online Article Text |
id | pubmed-4939346 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-49393462016-07-17 Analgesic Neural Circuits Are Activated by Electroacupuncture at Two Sets of Acupoints Hu, Man-Li Qiu, Zheng-Ying Hu, Kuang Ding, Ming-Xing Evid Based Complement Alternat Med Research Article To investigate analgesic neural circuits activated by electroacupuncture (EA) at different sets of acupoints in the brain, goats were stimulated by EA at set of Baihui-Santai acupoints or set of Housanli acupoints for 30 min. The pain threshold was measured using the potassium iontophoresis method. The levels of c-Fos were determined with Streptavidin-Biotin Complex immunohistochemistry. The results showed pain threshold induced by EA at set of Baihui-Santai acupoints was 44.74% ± 4.56% higher than that by EA at set of Housanli acupoints (32.64% ± 5.04%). Compared with blank control, EA at two sets of acupoints increased c-Fos expression in the medial septal nucleus (MSN), the arcuate nucleus (ARC), the nucleus amygdala basalis (AB), the lateral habenula nucleus (HL), the ventrolateral periaqueductal grey (vlPAG), the locus coeruleus (LC), the nucleus raphe magnus (NRM), the pituitary gland, and spinal cord dorsal horn (SDH). Compared with EA at set of Housanli points, EA at set of Baihui-Santai points induced increased c-Fos expression in AB but decrease in MSN, the paraventricular nucleus of the hypothalamus, HL, and SDH. It suggests that ARC-PAG-NRM/LC-SDH and the hypothalamus-pituitary may be the common activated neural pathways taking part in EA-induced analgesia at the two sets of acupoints. Hindawi Publishing Corporation 2016 2016-06-27 /pmc/articles/PMC4939346/ /pubmed/27429635 http://dx.doi.org/10.1155/2016/3840202 Text en Copyright © 2016 Man-Li Hu et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Hu, Man-Li Qiu, Zheng-Ying Hu, Kuang Ding, Ming-Xing Analgesic Neural Circuits Are Activated by Electroacupuncture at Two Sets of Acupoints |
title | Analgesic Neural Circuits Are Activated by Electroacupuncture at Two Sets of Acupoints |
title_full | Analgesic Neural Circuits Are Activated by Electroacupuncture at Two Sets of Acupoints |
title_fullStr | Analgesic Neural Circuits Are Activated by Electroacupuncture at Two Sets of Acupoints |
title_full_unstemmed | Analgesic Neural Circuits Are Activated by Electroacupuncture at Two Sets of Acupoints |
title_short | Analgesic Neural Circuits Are Activated by Electroacupuncture at Two Sets of Acupoints |
title_sort | analgesic neural circuits are activated by electroacupuncture at two sets of acupoints |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4939346/ https://www.ncbi.nlm.nih.gov/pubmed/27429635 http://dx.doi.org/10.1155/2016/3840202 |
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