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From Inflammation to Prostate Cancer: The Role of Inflammasomes
Inflammation-associated studies entice specific attention due to inflammation's role in multiple stages of prostate cancer development. However, mechanistic regulation of inflammation inciting prostate cancer remains largely uncharacterized. A focused class of inflammatory regulators known as i...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4939357/ https://www.ncbi.nlm.nih.gov/pubmed/27429614 http://dx.doi.org/10.1155/2016/3140372 |
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author | Karan, Dev Dubey, Seema |
author_facet | Karan, Dev Dubey, Seema |
author_sort | Karan, Dev |
collection | PubMed |
description | Inflammation-associated studies entice specific attention due to inflammation's role in multiple stages of prostate cancer development. However, mechanistic regulation of inflammation inciting prostate cancer remains largely uncharacterized. A focused class of inflammatory regulators known as inflammasomes has recently gained attention in cancer development. Inflammasomes are a multiprotein complex that drives a cascade of proinflammatory cytokines regulating various cellular activities. Inflammasomes activation is linked with infection, stress, or danger signals, which are common events within the prostate gland. In this study, we review the potential of inflammasomes in understanding the role of inflammation in prostate cancer. |
format | Online Article Text |
id | pubmed-4939357 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-49393572016-07-17 From Inflammation to Prostate Cancer: The Role of Inflammasomes Karan, Dev Dubey, Seema Adv Urol Review Article Inflammation-associated studies entice specific attention due to inflammation's role in multiple stages of prostate cancer development. However, mechanistic regulation of inflammation inciting prostate cancer remains largely uncharacterized. A focused class of inflammatory regulators known as inflammasomes has recently gained attention in cancer development. Inflammasomes are a multiprotein complex that drives a cascade of proinflammatory cytokines regulating various cellular activities. Inflammasomes activation is linked with infection, stress, or danger signals, which are common events within the prostate gland. In this study, we review the potential of inflammasomes in understanding the role of inflammation in prostate cancer. Hindawi Publishing Corporation 2016 2016-06-27 /pmc/articles/PMC4939357/ /pubmed/27429614 http://dx.doi.org/10.1155/2016/3140372 Text en Copyright © 2016 D. Karan and S. Dubey. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Karan, Dev Dubey, Seema From Inflammation to Prostate Cancer: The Role of Inflammasomes |
title | From Inflammation to Prostate Cancer: The Role of Inflammasomes |
title_full | From Inflammation to Prostate Cancer: The Role of Inflammasomes |
title_fullStr | From Inflammation to Prostate Cancer: The Role of Inflammasomes |
title_full_unstemmed | From Inflammation to Prostate Cancer: The Role of Inflammasomes |
title_short | From Inflammation to Prostate Cancer: The Role of Inflammasomes |
title_sort | from inflammation to prostate cancer: the role of inflammasomes |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4939357/ https://www.ncbi.nlm.nih.gov/pubmed/27429614 http://dx.doi.org/10.1155/2016/3140372 |
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