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Maladaptive Plasticity in Aphasia: Brain Activation Maps Underlying Verb Retrieval Errors
Anomia, or impaired word retrieval, is the most widespread symptom of aphasia, an acquired language impairment secondary to brain damage. In the last decades, functional neuroimaging techniques have enabled studying the neural basis underlying anomia and its recovery. The present study aimed to expl...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4939358/ https://www.ncbi.nlm.nih.gov/pubmed/27429808 http://dx.doi.org/10.1155/2016/4806492 |
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author | Spielmann, Kerstin Durand, Edith Marcotte, Karine Ansaldo, Ana Inés |
author_facet | Spielmann, Kerstin Durand, Edith Marcotte, Karine Ansaldo, Ana Inés |
author_sort | Spielmann, Kerstin |
collection | PubMed |
description | Anomia, or impaired word retrieval, is the most widespread symptom of aphasia, an acquired language impairment secondary to brain damage. In the last decades, functional neuroimaging techniques have enabled studying the neural basis underlying anomia and its recovery. The present study aimed to explore maladaptive plasticity in persistent verb anomia, in three male participants with chronic nonfluent aphasia. Brain activation maps associated with semantic verb paraphasia occurring within an oral picture-naming task were identified with an event-related fMRI paradigm. These maps were compared with those obtained in our previous study examining adaptive plasticity (i.e., successful verb naming) in the same participants. The results show that activation patterns related to semantic verb paraphasia and successful verb naming comprise a number of common areas, contributing to both maladaptive and adaptive neuroplasticity mechanisms. This finding suggests that the segregation of brain areas provides only a partial view of the neural basis of verb anomia and successful verb naming. Therefore, it indicates the importance of network approaches which may better capture the complexity of maladaptive and adaptive neuroplasticity mechanisms in anomia recovery. |
format | Online Article Text |
id | pubmed-4939358 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-49393582016-07-17 Maladaptive Plasticity in Aphasia: Brain Activation Maps Underlying Verb Retrieval Errors Spielmann, Kerstin Durand, Edith Marcotte, Karine Ansaldo, Ana Inés Neural Plast Research Article Anomia, or impaired word retrieval, is the most widespread symptom of aphasia, an acquired language impairment secondary to brain damage. In the last decades, functional neuroimaging techniques have enabled studying the neural basis underlying anomia and its recovery. The present study aimed to explore maladaptive plasticity in persistent verb anomia, in three male participants with chronic nonfluent aphasia. Brain activation maps associated with semantic verb paraphasia occurring within an oral picture-naming task were identified with an event-related fMRI paradigm. These maps were compared with those obtained in our previous study examining adaptive plasticity (i.e., successful verb naming) in the same participants. The results show that activation patterns related to semantic verb paraphasia and successful verb naming comprise a number of common areas, contributing to both maladaptive and adaptive neuroplasticity mechanisms. This finding suggests that the segregation of brain areas provides only a partial view of the neural basis of verb anomia and successful verb naming. Therefore, it indicates the importance of network approaches which may better capture the complexity of maladaptive and adaptive neuroplasticity mechanisms in anomia recovery. Hindawi Publishing Corporation 2016 2016-06-27 /pmc/articles/PMC4939358/ /pubmed/27429808 http://dx.doi.org/10.1155/2016/4806492 Text en Copyright © 2016 Kerstin Spielmann et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Spielmann, Kerstin Durand, Edith Marcotte, Karine Ansaldo, Ana Inés Maladaptive Plasticity in Aphasia: Brain Activation Maps Underlying Verb Retrieval Errors |
title | Maladaptive Plasticity in Aphasia: Brain Activation Maps Underlying Verb Retrieval Errors |
title_full | Maladaptive Plasticity in Aphasia: Brain Activation Maps Underlying Verb Retrieval Errors |
title_fullStr | Maladaptive Plasticity in Aphasia: Brain Activation Maps Underlying Verb Retrieval Errors |
title_full_unstemmed | Maladaptive Plasticity in Aphasia: Brain Activation Maps Underlying Verb Retrieval Errors |
title_short | Maladaptive Plasticity in Aphasia: Brain Activation Maps Underlying Verb Retrieval Errors |
title_sort | maladaptive plasticity in aphasia: brain activation maps underlying verb retrieval errors |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4939358/ https://www.ncbi.nlm.nih.gov/pubmed/27429808 http://dx.doi.org/10.1155/2016/4806492 |
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