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New Pathogenic Concepts and Therapeutic Approaches to Oxidative Stress in Chronic Kidney Disease

In chronic kidney disease inflammatory processes and stimulation of immune cells result in overproduction of free radicals. In combination with a reduced antioxidant capacity this causes oxidative stress. This review focuses on current pathogenic concepts of oxidative stress for the decline of kidne...

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Autores principales: Pedraza-Chaverri, José, Sánchez-Lozada, Laura G., Osorio-Alonso, Horacio, Tapia, Edilia, Scholze, Alexandra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4939360/
https://www.ncbi.nlm.nih.gov/pubmed/27429711
http://dx.doi.org/10.1155/2016/6043601
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author Pedraza-Chaverri, José
Sánchez-Lozada, Laura G.
Osorio-Alonso, Horacio
Tapia, Edilia
Scholze, Alexandra
author_facet Pedraza-Chaverri, José
Sánchez-Lozada, Laura G.
Osorio-Alonso, Horacio
Tapia, Edilia
Scholze, Alexandra
author_sort Pedraza-Chaverri, José
collection PubMed
description In chronic kidney disease inflammatory processes and stimulation of immune cells result in overproduction of free radicals. In combination with a reduced antioxidant capacity this causes oxidative stress. This review focuses on current pathogenic concepts of oxidative stress for the decline of kidney function and development of cardiovascular complications. We discuss the impact of mitochondrial alterations and dysfunction, a pathogenic role for hyperuricemia, and disturbances of vitamin D metabolism and signal transduction. Recent antioxidant therapy options including the use of vitamin D and pharmacologic therapies for hyperuricemia are discussed. Finally, we review some new therapy options in diabetic nephropathy including antidiabetic agents (noninsulin dependent), plant antioxidants, and food components as alternative antioxidant therapies.
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spelling pubmed-49393602016-07-17 New Pathogenic Concepts and Therapeutic Approaches to Oxidative Stress in Chronic Kidney Disease Pedraza-Chaverri, José Sánchez-Lozada, Laura G. Osorio-Alonso, Horacio Tapia, Edilia Scholze, Alexandra Oxid Med Cell Longev Review Article In chronic kidney disease inflammatory processes and stimulation of immune cells result in overproduction of free radicals. In combination with a reduced antioxidant capacity this causes oxidative stress. This review focuses on current pathogenic concepts of oxidative stress for the decline of kidney function and development of cardiovascular complications. We discuss the impact of mitochondrial alterations and dysfunction, a pathogenic role for hyperuricemia, and disturbances of vitamin D metabolism and signal transduction. Recent antioxidant therapy options including the use of vitamin D and pharmacologic therapies for hyperuricemia are discussed. Finally, we review some new therapy options in diabetic nephropathy including antidiabetic agents (noninsulin dependent), plant antioxidants, and food components as alternative antioxidant therapies. Hindawi Publishing Corporation 2016 2016-06-27 /pmc/articles/PMC4939360/ /pubmed/27429711 http://dx.doi.org/10.1155/2016/6043601 Text en Copyright © 2016 José Pedraza-Chaverri et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Pedraza-Chaverri, José
Sánchez-Lozada, Laura G.
Osorio-Alonso, Horacio
Tapia, Edilia
Scholze, Alexandra
New Pathogenic Concepts and Therapeutic Approaches to Oxidative Stress in Chronic Kidney Disease
title New Pathogenic Concepts and Therapeutic Approaches to Oxidative Stress in Chronic Kidney Disease
title_full New Pathogenic Concepts and Therapeutic Approaches to Oxidative Stress in Chronic Kidney Disease
title_fullStr New Pathogenic Concepts and Therapeutic Approaches to Oxidative Stress in Chronic Kidney Disease
title_full_unstemmed New Pathogenic Concepts and Therapeutic Approaches to Oxidative Stress in Chronic Kidney Disease
title_short New Pathogenic Concepts and Therapeutic Approaches to Oxidative Stress in Chronic Kidney Disease
title_sort new pathogenic concepts and therapeutic approaches to oxidative stress in chronic kidney disease
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4939360/
https://www.ncbi.nlm.nih.gov/pubmed/27429711
http://dx.doi.org/10.1155/2016/6043601
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