Cargando…
Controversies Surrounding Clostridium difficile Infection in Infants and Young Children
Clostridium difficile is a frequent cause of antibiotic-associated diarrhea in adults and older children. However, as many as 80% of infants can be asymptomatically colonized. The reasons for this have not been well established but are believed to be due to differences in toxin receptors or toxin in...
Autores principales: | , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2014
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4939517/ https://www.ncbi.nlm.nih.gov/pubmed/27417466 http://dx.doi.org/10.3390/children1010040 |
_version_ | 1782442015231836160 |
---|---|
author | Nicholson, Maribeth R. Thomsen, Isaac P. Edwards, Kathryn M. |
author_facet | Nicholson, Maribeth R. Thomsen, Isaac P. Edwards, Kathryn M. |
author_sort | Nicholson, Maribeth R. |
collection | PubMed |
description | Clostridium difficile is a frequent cause of antibiotic-associated diarrhea in adults and older children. However, as many as 80% of infants can be asymptomatically colonized. The reasons for this have not been well established but are believed to be due to differences in toxin receptors or toxin internalization. Determining which children who test positive for C. difficile warrant treatment is exceedingly difficult, especially in the setting of increased rates of detection and the rising risk of disease in children lacking classic risk factors for C. difficile. |
format | Online Article Text |
id | pubmed-4939517 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-49395172016-07-12 Controversies Surrounding Clostridium difficile Infection in Infants and Young Children Nicholson, Maribeth R. Thomsen, Isaac P. Edwards, Kathryn M. Children (Basel) Review Clostridium difficile is a frequent cause of antibiotic-associated diarrhea in adults and older children. However, as many as 80% of infants can be asymptomatically colonized. The reasons for this have not been well established but are believed to be due to differences in toxin receptors or toxin internalization. Determining which children who test positive for C. difficile warrant treatment is exceedingly difficult, especially in the setting of increased rates of detection and the rising risk of disease in children lacking classic risk factors for C. difficile. MDPI 2014-06-13 /pmc/articles/PMC4939517/ /pubmed/27417466 http://dx.doi.org/10.3390/children1010040 Text en © 2014 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/). |
spellingShingle | Review Nicholson, Maribeth R. Thomsen, Isaac P. Edwards, Kathryn M. Controversies Surrounding Clostridium difficile Infection in Infants and Young Children |
title | Controversies Surrounding Clostridium difficile Infection in Infants and Young Children |
title_full | Controversies Surrounding Clostridium difficile Infection in Infants and Young Children |
title_fullStr | Controversies Surrounding Clostridium difficile Infection in Infants and Young Children |
title_full_unstemmed | Controversies Surrounding Clostridium difficile Infection in Infants and Young Children |
title_short | Controversies Surrounding Clostridium difficile Infection in Infants and Young Children |
title_sort | controversies surrounding clostridium difficile infection in infants and young children |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4939517/ https://www.ncbi.nlm.nih.gov/pubmed/27417466 http://dx.doi.org/10.3390/children1010040 |
work_keys_str_mv | AT nicholsonmaribethr controversiessurroundingclostridiumdifficileinfectionininfantsandyoungchildren AT thomsenisaacp controversiessurroundingclostridiumdifficileinfectionininfantsandyoungchildren AT edwardskathrynm controversiessurroundingclostridiumdifficileinfectionininfantsandyoungchildren |