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Supplementation of Coenzyme Q10 among Patients with Type 2 Diabetes Mellitus
Type 2 diabetes mellitus (T2DM) is a major cause of morbidity and mortality with ever increasing prevalence in the United States and worldwide. There is growing body of evidence suggesting that mitochondrial dysfunction secondary to oxidative stress plays a critical role in the pathogenesis of T2DM....
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4939545/ https://www.ncbi.nlm.nih.gov/pubmed/27417763 http://dx.doi.org/10.3390/healthcare3020296 |
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author | Shen, Qiuhua Pierce, Janet D. |
author_facet | Shen, Qiuhua Pierce, Janet D. |
author_sort | Shen, Qiuhua |
collection | PubMed |
description | Type 2 diabetes mellitus (T2DM) is a major cause of morbidity and mortality with ever increasing prevalence in the United States and worldwide. There is growing body of evidence suggesting that mitochondrial dysfunction secondary to oxidative stress plays a critical role in the pathogenesis of T2DM. Coenzyme Q10 is an important micronutrient acting on the electron transport chain of the mitochondria with two major functions: (1) synthesis of adenosine triphosphate (ATP); and (2) a potent antioxidant. Deficiency in coenzyme Q10 is often seen in patients with T2DM. Whether restoration of coenzyme Q10 will help alleviate oxidative stress, preserve mitochondrial function, and thus improve glycemic control in T2DM is unclear. This article reviews the relationships among oxidative stress, mitochondrial dysfunction, and T2DM and examines the evidence for potential use of coenzyme Q10 as a supplement for the treatment of T2DM. |
format | Online Article Text |
id | pubmed-4939545 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-49395452016-07-12 Supplementation of Coenzyme Q10 among Patients with Type 2 Diabetes Mellitus Shen, Qiuhua Pierce, Janet D. Healthcare (Basel) Review Type 2 diabetes mellitus (T2DM) is a major cause of morbidity and mortality with ever increasing prevalence in the United States and worldwide. There is growing body of evidence suggesting that mitochondrial dysfunction secondary to oxidative stress plays a critical role in the pathogenesis of T2DM. Coenzyme Q10 is an important micronutrient acting on the electron transport chain of the mitochondria with two major functions: (1) synthesis of adenosine triphosphate (ATP); and (2) a potent antioxidant. Deficiency in coenzyme Q10 is often seen in patients with T2DM. Whether restoration of coenzyme Q10 will help alleviate oxidative stress, preserve mitochondrial function, and thus improve glycemic control in T2DM is unclear. This article reviews the relationships among oxidative stress, mitochondrial dysfunction, and T2DM and examines the evidence for potential use of coenzyme Q10 as a supplement for the treatment of T2DM. MDPI 2015-05-21 /pmc/articles/PMC4939545/ /pubmed/27417763 http://dx.doi.org/10.3390/healthcare3020296 Text en © 2015 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Shen, Qiuhua Pierce, Janet D. Supplementation of Coenzyme Q10 among Patients with Type 2 Diabetes Mellitus |
title | Supplementation of Coenzyme Q10 among Patients with Type 2 Diabetes Mellitus |
title_full | Supplementation of Coenzyme Q10 among Patients with Type 2 Diabetes Mellitus |
title_fullStr | Supplementation of Coenzyme Q10 among Patients with Type 2 Diabetes Mellitus |
title_full_unstemmed | Supplementation of Coenzyme Q10 among Patients with Type 2 Diabetes Mellitus |
title_short | Supplementation of Coenzyme Q10 among Patients with Type 2 Diabetes Mellitus |
title_sort | supplementation of coenzyme q10 among patients with type 2 diabetes mellitus |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4939545/ https://www.ncbi.nlm.nih.gov/pubmed/27417763 http://dx.doi.org/10.3390/healthcare3020296 |
work_keys_str_mv | AT shenqiuhua supplementationofcoenzymeq10amongpatientswithtype2diabetesmellitus AT piercejanetd supplementationofcoenzymeq10amongpatientswithtype2diabetesmellitus |