A Serial shRNA Screen for Roadblocks to Reprogramming Identifies the Protein Modifier SUMO2

The generation of induced pluripotent stem cells (iPSCs) from differentiated cells following forced expression of OCT4, KLF4, SOX2, and C-MYC (OKSM) is slow and inefficient, suggesting that transcription factors have to overcome somatic barriers that resist cell fate change. Here, we performed an un...

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Detalles Bibliográficos
Autores principales: Borkent, Marti, Bennett, Brian D., Lackford, Brad, Bar-Nur, Ori, Brumbaugh, Justin, Wang, Li, Du, Ying, Fargo, David C., Apostolou, Effie, Cheloufi, Sihem, Maherali, Nimet, Elledge, Stephen J., Hu, Guang, Hochedlinger, Konrad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4939549/
https://www.ncbi.nlm.nih.gov/pubmed/26947976
http://dx.doi.org/10.1016/j.stemcr.2016.02.004

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