BLT(1) signalling protects the liver against acetaminophen hepatotoxicity by preventing excessive accumulation of hepatic neutrophils

Leukotriene B(4) (LTB(4)) is a potent chemoattractant for neutrophils. Signalling of LTB(4) receptor type 1 (BLT(1)) has pro-inflammatory functions through neutrophil recruitment. In this study, we investigated whether BLT(1) signalling plays a role in acetaminophen (APAP)-induced liver injury by af...

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Detalles Bibliográficos
Autores principales: Kojo, Ken, Ito, Yoshiya, Eshima, Koji, Nishizawa, Nobuyuki, Ohkubo, Hirotoki, Yokomizo, Takehiko, Shimizu, Takao, Watanabe, Masahiko, Majima, Masataka
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4939602/
https://www.ncbi.nlm.nih.gov/pubmed/27404729
http://dx.doi.org/10.1038/srep29650

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