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Pazopanib in Primary Cardiac Angiosarcoma of the Right Atrium: A Case Report

Primary heart tumors are an extremely rare oncological entity with primary cardiac sarcomas usually representing 20% of all primary cardiac tumorous lesions [Shanmugam: Eur J Cardiothorac Surg 2006;29: 925–932; Orlandi et al.: J Thorac Oncol 2010;5: 1483–1489]. Angiosarcoma is the most prevalent his...

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Detalles Bibliográficos
Autores principales: Schur, Sophie, Hamacher, Rainer, Brodowicz, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: S. Karger AG 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4939669/
https://www.ncbi.nlm.nih.gov/pubmed/27462238
http://dx.doi.org/10.1159/000447088
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author Schur, Sophie
Hamacher, Rainer
Brodowicz, Thomas
author_facet Schur, Sophie
Hamacher, Rainer
Brodowicz, Thomas
author_sort Schur, Sophie
collection PubMed
description Primary heart tumors are an extremely rare oncological entity with primary cardiac sarcomas usually representing 20% of all primary cardiac tumorous lesions [Shanmugam: Eur J Cardiothorac Surg 2006;29: 925–932; Orlandi et al.: J Thorac Oncol 2010;5: 1483–1489]. Angiosarcoma is the most prevalent histology and despite a multidisciplinary approach tends to have a dismal prognosis [Shanmugam: Eur J Cardiothorac Surg 2006;29: 925–932; Fury et al.: Cancer J 2005;11: 241–247]. Based on the prevailing literature, we report a 48-year-old woman diagnosed with primary metastatic cardiac angiosarcoma who showed a severe hypersensitivity reaction to conventional chemotherapy with taxanes but an excellent response to treatment with the multitargeted receptor tyrosine kinase inhibitor pazopanib.
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spelling pubmed-49396692016-07-26 Pazopanib in Primary Cardiac Angiosarcoma of the Right Atrium: A Case Report Schur, Sophie Hamacher, Rainer Brodowicz, Thomas Case Rep Oncol Case Report Primary heart tumors are an extremely rare oncological entity with primary cardiac sarcomas usually representing 20% of all primary cardiac tumorous lesions [Shanmugam: Eur J Cardiothorac Surg 2006;29: 925–932; Orlandi et al.: J Thorac Oncol 2010;5: 1483–1489]. Angiosarcoma is the most prevalent histology and despite a multidisciplinary approach tends to have a dismal prognosis [Shanmugam: Eur J Cardiothorac Surg 2006;29: 925–932; Fury et al.: Cancer J 2005;11: 241–247]. Based on the prevailing literature, we report a 48-year-old woman diagnosed with primary metastatic cardiac angiosarcoma who showed a severe hypersensitivity reaction to conventional chemotherapy with taxanes but an excellent response to treatment with the multitargeted receptor tyrosine kinase inhibitor pazopanib. S. Karger AG 2016-06-27 /pmc/articles/PMC4939669/ /pubmed/27462238 http://dx.doi.org/10.1159/000447088 Text en Copyright © 2016 by S. Karger AG, Basel http://creativecommons.org/licenses/by-nc/4.0/ This article is licensed under the Creative Commons Attribution-NonCommercial-4.0 International License (CC BY-NC) (http://www.karger.com/Services/OpenAccessLicense). Usage and distribution for commercial purposes requires written permission.
spellingShingle Case Report
Schur, Sophie
Hamacher, Rainer
Brodowicz, Thomas
Pazopanib in Primary Cardiac Angiosarcoma of the Right Atrium: A Case Report
title Pazopanib in Primary Cardiac Angiosarcoma of the Right Atrium: A Case Report
title_full Pazopanib in Primary Cardiac Angiosarcoma of the Right Atrium: A Case Report
title_fullStr Pazopanib in Primary Cardiac Angiosarcoma of the Right Atrium: A Case Report
title_full_unstemmed Pazopanib in Primary Cardiac Angiosarcoma of the Right Atrium: A Case Report
title_short Pazopanib in Primary Cardiac Angiosarcoma of the Right Atrium: A Case Report
title_sort pazopanib in primary cardiac angiosarcoma of the right atrium: a case report
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4939669/
https://www.ncbi.nlm.nih.gov/pubmed/27462238
http://dx.doi.org/10.1159/000447088
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