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Pazopanib in Primary Cardiac Angiosarcoma of the Right Atrium: A Case Report
Primary heart tumors are an extremely rare oncological entity with primary cardiac sarcomas usually representing 20% of all primary cardiac tumorous lesions [Shanmugam: Eur J Cardiothorac Surg 2006;29: 925–932; Orlandi et al.: J Thorac Oncol 2010;5: 1483–1489]. Angiosarcoma is the most prevalent his...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
S. Karger AG
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4939669/ https://www.ncbi.nlm.nih.gov/pubmed/27462238 http://dx.doi.org/10.1159/000447088 |
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author | Schur, Sophie Hamacher, Rainer Brodowicz, Thomas |
author_facet | Schur, Sophie Hamacher, Rainer Brodowicz, Thomas |
author_sort | Schur, Sophie |
collection | PubMed |
description | Primary heart tumors are an extremely rare oncological entity with primary cardiac sarcomas usually representing 20% of all primary cardiac tumorous lesions [Shanmugam: Eur J Cardiothorac Surg 2006;29: 925–932; Orlandi et al.: J Thorac Oncol 2010;5: 1483–1489]. Angiosarcoma is the most prevalent histology and despite a multidisciplinary approach tends to have a dismal prognosis [Shanmugam: Eur J Cardiothorac Surg 2006;29: 925–932; Fury et al.: Cancer J 2005;11: 241–247]. Based on the prevailing literature, we report a 48-year-old woman diagnosed with primary metastatic cardiac angiosarcoma who showed a severe hypersensitivity reaction to conventional chemotherapy with taxanes but an excellent response to treatment with the multitargeted receptor tyrosine kinase inhibitor pazopanib. |
format | Online Article Text |
id | pubmed-4939669 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | S. Karger AG |
record_format | MEDLINE/PubMed |
spelling | pubmed-49396692016-07-26 Pazopanib in Primary Cardiac Angiosarcoma of the Right Atrium: A Case Report Schur, Sophie Hamacher, Rainer Brodowicz, Thomas Case Rep Oncol Case Report Primary heart tumors are an extremely rare oncological entity with primary cardiac sarcomas usually representing 20% of all primary cardiac tumorous lesions [Shanmugam: Eur J Cardiothorac Surg 2006;29: 925–932; Orlandi et al.: J Thorac Oncol 2010;5: 1483–1489]. Angiosarcoma is the most prevalent histology and despite a multidisciplinary approach tends to have a dismal prognosis [Shanmugam: Eur J Cardiothorac Surg 2006;29: 925–932; Fury et al.: Cancer J 2005;11: 241–247]. Based on the prevailing literature, we report a 48-year-old woman diagnosed with primary metastatic cardiac angiosarcoma who showed a severe hypersensitivity reaction to conventional chemotherapy with taxanes but an excellent response to treatment with the multitargeted receptor tyrosine kinase inhibitor pazopanib. S. Karger AG 2016-06-27 /pmc/articles/PMC4939669/ /pubmed/27462238 http://dx.doi.org/10.1159/000447088 Text en Copyright © 2016 by S. Karger AG, Basel http://creativecommons.org/licenses/by-nc/4.0/ This article is licensed under the Creative Commons Attribution-NonCommercial-4.0 International License (CC BY-NC) (http://www.karger.com/Services/OpenAccessLicense). Usage and distribution for commercial purposes requires written permission. |
spellingShingle | Case Report Schur, Sophie Hamacher, Rainer Brodowicz, Thomas Pazopanib in Primary Cardiac Angiosarcoma of the Right Atrium: A Case Report |
title | Pazopanib in Primary Cardiac Angiosarcoma of the Right Atrium: A Case Report |
title_full | Pazopanib in Primary Cardiac Angiosarcoma of the Right Atrium: A Case Report |
title_fullStr | Pazopanib in Primary Cardiac Angiosarcoma of the Right Atrium: A Case Report |
title_full_unstemmed | Pazopanib in Primary Cardiac Angiosarcoma of the Right Atrium: A Case Report |
title_short | Pazopanib in Primary Cardiac Angiosarcoma of the Right Atrium: A Case Report |
title_sort | pazopanib in primary cardiac angiosarcoma of the right atrium: a case report |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4939669/ https://www.ncbi.nlm.nih.gov/pubmed/27462238 http://dx.doi.org/10.1159/000447088 |
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