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Successful Eradication of Hepatitis C Virus by Interferon-Free Regimens in Two Patients with Advanced Liver Fibrosis following Kidney Transplantation

Hepatitis C virus (HCV) infection leads to acute and chronic hepatitis, cirrhosis, and hepatocellular carcinoma. Following kidney transplantation, HCV increases the risk of graft loss and patient mortality compared with uninfected patients. The achievement of a sustained virological response with an...

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Autores principales: Sasaki, Reina, Kanda, Tatsuo, Yasui, Shin, Haga, Yuki, Nakamura, Masato, Yamato, Mutsumi, Wu, Shuang, Nakamoto, Shingo, Arai, Makoto, Mikami, Shigeru, Miyauchi, Hideaki, Matsubara, Hisahiro, Yokosuka, Osamu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: S. Karger AG 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4939684/
https://www.ncbi.nlm.nih.gov/pubmed/27462193
http://dx.doi.org/10.1159/000445374
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author Sasaki, Reina
Kanda, Tatsuo
Yasui, Shin
Haga, Yuki
Nakamura, Masato
Yamato, Mutsumi
Wu, Shuang
Nakamoto, Shingo
Arai, Makoto
Mikami, Shigeru
Miyauchi, Hideaki
Matsubara, Hisahiro
Yokosuka, Osamu
author_facet Sasaki, Reina
Kanda, Tatsuo
Yasui, Shin
Haga, Yuki
Nakamura, Masato
Yamato, Mutsumi
Wu, Shuang
Nakamoto, Shingo
Arai, Makoto
Mikami, Shigeru
Miyauchi, Hideaki
Matsubara, Hisahiro
Yokosuka, Osamu
author_sort Sasaki, Reina
collection PubMed
description Hepatitis C virus (HCV) infection leads to acute and chronic hepatitis, cirrhosis, and hepatocellular carcinoma. Following kidney transplantation, HCV increases the risk of graft loss and patient mortality compared with uninfected patients. The achievement of a sustained virological response with antiviral therapy improves survival and diminishes the risk of hepatic decompensation in HCV patients after a kidney transplant. It has been reported that direct-acting antivirals (DAAs) are relatively safe and highly effective for the eradication of HCV in patients who are liver transplant recipients. In the present study, we investigated HCV eradication via interferon-free therapies with DAAs in two HCV patients with advanced liver fibrosis following renal transplantation. In both cases, the interferon-free regimens with DAAs were effective in eradicating HCV in the patients after kidney transplantation. No adverse events caused by interferon were identified with the exception of anemia. Interferon-free regimens with DAAs for recurrent HCV in patients following kidney transplantation are relatively safe and effective. However, attention should be focused on anemia during these treatments.
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spelling pubmed-49396842016-07-26 Successful Eradication of Hepatitis C Virus by Interferon-Free Regimens in Two Patients with Advanced Liver Fibrosis following Kidney Transplantation Sasaki, Reina Kanda, Tatsuo Yasui, Shin Haga, Yuki Nakamura, Masato Yamato, Mutsumi Wu, Shuang Nakamoto, Shingo Arai, Makoto Mikami, Shigeru Miyauchi, Hideaki Matsubara, Hisahiro Yokosuka, Osamu Case Rep Gastroenterol Case Report Hepatitis C virus (HCV) infection leads to acute and chronic hepatitis, cirrhosis, and hepatocellular carcinoma. Following kidney transplantation, HCV increases the risk of graft loss and patient mortality compared with uninfected patients. The achievement of a sustained virological response with antiviral therapy improves survival and diminishes the risk of hepatic decompensation in HCV patients after a kidney transplant. It has been reported that direct-acting antivirals (DAAs) are relatively safe and highly effective for the eradication of HCV in patients who are liver transplant recipients. In the present study, we investigated HCV eradication via interferon-free therapies with DAAs in two HCV patients with advanced liver fibrosis following renal transplantation. In both cases, the interferon-free regimens with DAAs were effective in eradicating HCV in the patients after kidney transplantation. No adverse events caused by interferon were identified with the exception of anemia. Interferon-free regimens with DAAs for recurrent HCV in patients following kidney transplantation are relatively safe and effective. However, attention should be focused on anemia during these treatments. S. Karger AG 2016-05-27 /pmc/articles/PMC4939684/ /pubmed/27462193 http://dx.doi.org/10.1159/000445374 Text en Copyright © 2016 by S. Karger AG, Basel http://creativecommons.org/licenses/by-nc/4.0/ This article is licensed under the Creative Commons Attribution-NonCommercial-4.0 International License (CC BY-NC) (http://www.karger.com/Services/OpenAccessLicense). Usage and distribution for commercial purposes requires written permission.
spellingShingle Case Report
Sasaki, Reina
Kanda, Tatsuo
Yasui, Shin
Haga, Yuki
Nakamura, Masato
Yamato, Mutsumi
Wu, Shuang
Nakamoto, Shingo
Arai, Makoto
Mikami, Shigeru
Miyauchi, Hideaki
Matsubara, Hisahiro
Yokosuka, Osamu
Successful Eradication of Hepatitis C Virus by Interferon-Free Regimens in Two Patients with Advanced Liver Fibrosis following Kidney Transplantation
title Successful Eradication of Hepatitis C Virus by Interferon-Free Regimens in Two Patients with Advanced Liver Fibrosis following Kidney Transplantation
title_full Successful Eradication of Hepatitis C Virus by Interferon-Free Regimens in Two Patients with Advanced Liver Fibrosis following Kidney Transplantation
title_fullStr Successful Eradication of Hepatitis C Virus by Interferon-Free Regimens in Two Patients with Advanced Liver Fibrosis following Kidney Transplantation
title_full_unstemmed Successful Eradication of Hepatitis C Virus by Interferon-Free Regimens in Two Patients with Advanced Liver Fibrosis following Kidney Transplantation
title_short Successful Eradication of Hepatitis C Virus by Interferon-Free Regimens in Two Patients with Advanced Liver Fibrosis following Kidney Transplantation
title_sort successful eradication of hepatitis c virus by interferon-free regimens in two patients with advanced liver fibrosis following kidney transplantation
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4939684/
https://www.ncbi.nlm.nih.gov/pubmed/27462193
http://dx.doi.org/10.1159/000445374
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