The triptolide derivative MRx102 inhibits Wnt pathway activation and has potent anti-tumor effects in lung cancer

BACKGROUND: The natural compound triptolide has been shown to decrease cell proliferation and induce apoptosis and cellular senescence. We previously demonstrated that triptolide decreases tumor formation and metastasis of human non-small cell lung cancer cells (NSCLC). Due to the toxicity of tripto...

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Detalles Bibliográficos
Autores principales: Reno, Theresa A., Tong, Sun-Wing, Wu, Jun, Fidler, John M., Nelson, Rebecca, Kim, Jae Y., Raz, Dan J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4939706/
https://www.ncbi.nlm.nih.gov/pubmed/27400883
http://dx.doi.org/10.1186/s12885-016-2487-7

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