Cargando…

Poly(vinyl alcohol) Physical Hydrogels: Matrix-Mediated Drug Delivery Using Spontaneously Eroding Substrate

[Image: see text] Poly(vinyl alcohol) hydrogels have a long and successful history of applications in biomedicine. Historically, these matrices were developed to be nondegradable—limiting their utility to applications as permanent implants. For tissue engineering and drug delivery, herein we develop...

Descripción completa

Detalles Bibliográficos
Autores principales: Jensen, Bettina E. B., Dávila, Izaskun, Zelikin, Alexander N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2016
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4939746/
https://www.ncbi.nlm.nih.gov/pubmed/26958864
http://dx.doi.org/10.1021/acs.jpcb.6b01381
_version_ 1782442052109205504
author Jensen, Bettina E. B.
Dávila, Izaskun
Zelikin, Alexander N.
author_facet Jensen, Bettina E. B.
Dávila, Izaskun
Zelikin, Alexander N.
author_sort Jensen, Bettina E. B.
collection PubMed
description [Image: see text] Poly(vinyl alcohol) hydrogels have a long and successful history of applications in biomedicine. Historically, these matrices were developed to be nondegradable—limiting their utility to applications as permanent implants. For tissue engineering and drug delivery, herein we develop spontaneously eroding physical hydrogels based on PVA. We characterize in detail a mild, noncryogenic method of producing PVA physical hydrogels using poly(ethylene glycol) as a gelating agent, and investigate PVA molar mass as a means to define the kinetics of erosion of these biomaterials. PVA hydrogels are characterized for associated inflammatory response in adhering macrophages, antiproliferative effects mediated through delivery of cytotoxic drugs to myoblasts, and pro-proliferative activity achieved via presentation of conjugated growth factors to endothelial cells. Together, these data present a multiangle characterization of these novel multifunctional matrices for applications in tissue engineering and drug delivery mediated by implantable biomaterials.
format Online
Article
Text
id pubmed-4939746
institution National Center for Biotechnology Information
language English
publishDate 2016
publisher American Chemical Society
record_format MEDLINE/PubMed
spelling pubmed-49397462017-03-09 Poly(vinyl alcohol) Physical Hydrogels: Matrix-Mediated Drug Delivery Using Spontaneously Eroding Substrate Jensen, Bettina E. B. Dávila, Izaskun Zelikin, Alexander N. J Phys Chem B [Image: see text] Poly(vinyl alcohol) hydrogels have a long and successful history of applications in biomedicine. Historically, these matrices were developed to be nondegradable—limiting their utility to applications as permanent implants. For tissue engineering and drug delivery, herein we develop spontaneously eroding physical hydrogels based on PVA. We characterize in detail a mild, noncryogenic method of producing PVA physical hydrogels using poly(ethylene glycol) as a gelating agent, and investigate PVA molar mass as a means to define the kinetics of erosion of these biomaterials. PVA hydrogels are characterized for associated inflammatory response in adhering macrophages, antiproliferative effects mediated through delivery of cytotoxic drugs to myoblasts, and pro-proliferative activity achieved via presentation of conjugated growth factors to endothelial cells. Together, these data present a multiangle characterization of these novel multifunctional matrices for applications in tissue engineering and drug delivery mediated by implantable biomaterials. American Chemical Society 2016-03-09 2016-07-07 /pmc/articles/PMC4939746/ /pubmed/26958864 http://dx.doi.org/10.1021/acs.jpcb.6b01381 Text en Copyright © 2016 American Chemical Society This is an open access article published under an ACS AuthorChoice License (http://pubs.acs.org/page/policy/authorchoice_termsofuse.html) , which permits copying and redistribution of the article or any adaptations for non-commercial purposes.
spellingShingle Jensen, Bettina E. B.
Dávila, Izaskun
Zelikin, Alexander N.
Poly(vinyl alcohol) Physical Hydrogels: Matrix-Mediated Drug Delivery Using Spontaneously Eroding Substrate
title Poly(vinyl alcohol) Physical Hydrogels: Matrix-Mediated Drug Delivery Using Spontaneously Eroding Substrate
title_full Poly(vinyl alcohol) Physical Hydrogels: Matrix-Mediated Drug Delivery Using Spontaneously Eroding Substrate
title_fullStr Poly(vinyl alcohol) Physical Hydrogels: Matrix-Mediated Drug Delivery Using Spontaneously Eroding Substrate
title_full_unstemmed Poly(vinyl alcohol) Physical Hydrogels: Matrix-Mediated Drug Delivery Using Spontaneously Eroding Substrate
title_short Poly(vinyl alcohol) Physical Hydrogels: Matrix-Mediated Drug Delivery Using Spontaneously Eroding Substrate
title_sort poly(vinyl alcohol) physical hydrogels: matrix-mediated drug delivery using spontaneously eroding substrate
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4939746/
https://www.ncbi.nlm.nih.gov/pubmed/26958864
http://dx.doi.org/10.1021/acs.jpcb.6b01381
work_keys_str_mv AT jensenbettinaeb polyvinylalcoholphysicalhydrogelsmatrixmediateddrugdeliveryusingspontaneouslyerodingsubstrate
AT davilaizaskun polyvinylalcoholphysicalhydrogelsmatrixmediateddrugdeliveryusingspontaneouslyerodingsubstrate
AT zelikinalexandern polyvinylalcoholphysicalhydrogelsmatrixmediateddrugdeliveryusingspontaneouslyerodingsubstrate