Mechanism and Role of SOX2 Repression in Seminoma: Relevance to Human Germline Specification

Human male germ cell tumors (GCTs) are derived from primordial germ cells (PGCs). The master pluripotency regulator and neuroectodermal lineage effector transcription factor SOX2 is repressed in PGCs and the seminoma (SEM) subset of GCTs. The mechanism of SOX2 repression and its significance to GC a...

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Detalles Bibliográficos
Autores principales: Kushwaha, Ritu, Jagadish, Nirmala, Kustagi, Manjunath, Mendiratta, Geetu, Seandel, Marco, Soni, Rekha, Korkola, James E., Thodima, Venkata, Califano, Andrea, Bosl, George J., Chaganti, R.S.K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4939754/
https://www.ncbi.nlm.nih.gov/pubmed/27132888
http://dx.doi.org/10.1016/j.stemcr.2016.04.002

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