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Targeting a Rate-Promoting Vibration with an Allosteric Mediator in Lactate Dehydrogenase
[Image: see text] We present a new type of allosteric modulation in which a molecule bound outside the active site modifies the chemistry of an enzymatic reaction through rapid protein dynamics. As a test case for this type of allostery, we chose an enzyme with a well-characterized rate-promoting vi...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Chemical
Society
2016
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4939807/ https://www.ncbi.nlm.nih.gov/pubmed/27327209 http://dx.doi.org/10.1021/acs.jpclett.6b01209 |