Donepezil prevents RANK-induced bone loss via inhibition of osteoclast differentiation by downregulating acetylcholinesterase

OBJECTIVE: Donepezil, an inhibitor of acetylcholinesterase (AChE) targeting the brain, is a common medication for Alzheimer's disease. Interestingly, a recent clinical study found that administration of this agent is associated with lower risk of hip fracture independently of falling, suggestin...

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Detalles Bibliográficos
Autores principales: Sato, Tsuyoshi, Enoki, Yuichiro, Sakamoto, Yasushi, Yokota, Kazuhiro, Okubo, Masahiko, Matsumoto, Masahito, Hayashi, Naoki, Usui, Michihiko, Kokabu, Shoichiro, Mimura, Toshihide, Nakazato, Yoshihiko, Araki, Nobuo, Fukuda, Toru, Okazaki, Yasushi, Suda, Tatsuo, Takeda, Shu, Yoda, Tetsuya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4939821/
https://www.ncbi.nlm.nih.gov/pubmed/27441211
http://dx.doi.org/10.1016/j.heliyon.2015.e00013

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