Level of HE4 is Correlated with Diagnosis of Struma Ovarii: A Case Report

Patient: Female, 75 Final Diagnosis: Ovarian teratoma Symptoms: Chronic pelvic pain Medication: — Clinical Procedure: Tumor resection Specialty: Oncology OBJECTIVE: Rare disease BACKGROUND: Struma ovarii is a rare ovarian teratoma with non-specific clinical presentation that can mimic malignancy, especially when combined with the presence of ascites. Since the surgical procedures performed for benign and malignant tumors are quite different, pre-operative differential diagnosis is key. In this case report we compare the levels of biomarkers CA 125 and HE4 in the differential diagnosis of a suspicious ovarian tumor. CASE REPORT: A 75-year-old woman with a palpable mass at the left adnexa, ascites, and high levels of CA 125, underwent a subtotal abdominal hysterectomy and bilateral salpingo-oophorectomy. Histology reported benign struma ovarii. CONCLUSIONS: Even though transvaginal ultrasound and CA 125 levels suggested malignancy, HE4 measurements correctly diagnosed benignity.