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Somatic mutation in PIK3CA is a late event in cervical carcinogenesis

Somatic mutations in cervical intraepithelial neoplasia (CIN) are largely unknown. Here, we profiled 35 cervical carcinomas and 23 CIN grade 2/3 (CIN2/3) for mutations in 48 cancer‐related genes using a Next Generation Sequencing‐based cancer panel. PIK3CA exon 9 was the most frequently mutated locu...

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Detalles Bibliográficos
Autores principales:	Verlaat, Wina, Snijders, Peter JF, van Moorsel, Marinda IH, Bleeker, Maaike, Rozendaal, Lawrence, Sie, Daoud, Ylstra, Bauke, Meijer, Chris JLM, Steenbergen, Renske DM, Heideman, Daniëlle AM
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2015
Materias:	Brief Definitive Report
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4939891/ https://www.ncbi.nlm.nih.gov/pubmed/27499905 http://dx.doi.org/10.1002/cjp2.27

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