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Relationship between the iceA gene of Helicobacter pylori and clinical outcomes

BACKGROUND: The complex pathogenesis of Helicobacter pylori (H. pylori) and the features of the host influence the diverse clinical outcomes. A mass of studies about virulence genes have accelerated the exploration of pathogenesis of H. pylori infection. Induced by contact with epithelium gene A (ic...

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Autores principales: Huang, Xiaojun, Deng, Zhaomin, Zhang, Qiang, Li, Wanyi, Wang, Baoning, Li, Mingyuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4939977/
https://www.ncbi.nlm.nih.gov/pubmed/27462162
http://dx.doi.org/10.2147/TCRM.S107991
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author Huang, Xiaojun
Deng, Zhaomin
Zhang, Qiang
Li, Wanyi
Wang, Baoning
Li, Mingyuan
author_facet Huang, Xiaojun
Deng, Zhaomin
Zhang, Qiang
Li, Wanyi
Wang, Baoning
Li, Mingyuan
author_sort Huang, Xiaojun
collection PubMed
description BACKGROUND: The complex pathogenesis of Helicobacter pylori (H. pylori) and the features of the host influence the diverse clinical outcomes. A mass of studies about virulence genes have accelerated the exploration of pathogenesis of H. pylori infection. Induced by contact with epithelium gene A (iceA) is one of the biggest concerned virulence genes. In this study, we explored the relationship between iceA and the magnitude of the risk for clinical outcomes and the prevalence of iceA-positive H. pylori in People’s Republic of China and other countries. METHODS: We searched the electronic databases of PubMed, Embase, CNKI, VIP, and Wanfang by literature search strategy. The studies conforming to the inclusion criteria were assessed. With these data, we systematically analyzed the relationship between the iceA gene of H. pylori and clinical outcomes. RESULTS: Nineteen articles with 22 studies, a total of 2,657 cases, were involved in the study. The iceA1 gene was significantly associated with peptic ulcer disease (odds ratio =1.28, 95% confidence interval =1.03–1.60; P=0.03), especially in People’s Republic of China (odds ratio =1.40, 95% confidence interval =1.07–1.83; P=0.01). Moreover, the prevalence of iceA1 was significantly higher than iceA2 in People’s Republic of China (P<0.0001). The prevalence of both iceA1 and iceA2 was significantly different (P<0.0001) in People’s Republic of China and in other countries. CONCLUSION: The system analysis showed that infection with the iceA1-positive H. pylori significantly increased the overall risk for peptic ulcer disease, especially in People’s Republic of China. The iceA2 gene status and clinical outcome of H. pylori infection have no significant correlation. H. pylori iceA1 genotype is the major epidemic strain in People’s Republic of China.
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spelling pubmed-49399772016-07-26 Relationship between the iceA gene of Helicobacter pylori and clinical outcomes Huang, Xiaojun Deng, Zhaomin Zhang, Qiang Li, Wanyi Wang, Baoning Li, Mingyuan Ther Clin Risk Manag Original Research BACKGROUND: The complex pathogenesis of Helicobacter pylori (H. pylori) and the features of the host influence the diverse clinical outcomes. A mass of studies about virulence genes have accelerated the exploration of pathogenesis of H. pylori infection. Induced by contact with epithelium gene A (iceA) is one of the biggest concerned virulence genes. In this study, we explored the relationship between iceA and the magnitude of the risk for clinical outcomes and the prevalence of iceA-positive H. pylori in People’s Republic of China and other countries. METHODS: We searched the electronic databases of PubMed, Embase, CNKI, VIP, and Wanfang by literature search strategy. The studies conforming to the inclusion criteria were assessed. With these data, we systematically analyzed the relationship between the iceA gene of H. pylori and clinical outcomes. RESULTS: Nineteen articles with 22 studies, a total of 2,657 cases, were involved in the study. The iceA1 gene was significantly associated with peptic ulcer disease (odds ratio =1.28, 95% confidence interval =1.03–1.60; P=0.03), especially in People’s Republic of China (odds ratio =1.40, 95% confidence interval =1.07–1.83; P=0.01). Moreover, the prevalence of iceA1 was significantly higher than iceA2 in People’s Republic of China (P<0.0001). The prevalence of both iceA1 and iceA2 was significantly different (P<0.0001) in People’s Republic of China and in other countries. CONCLUSION: The system analysis showed that infection with the iceA1-positive H. pylori significantly increased the overall risk for peptic ulcer disease, especially in People’s Republic of China. The iceA2 gene status and clinical outcome of H. pylori infection have no significant correlation. H. pylori iceA1 genotype is the major epidemic strain in People’s Republic of China. Dove Medical Press 2016-07-06 /pmc/articles/PMC4939977/ /pubmed/27462162 http://dx.doi.org/10.2147/TCRM.S107991 Text en © 2016 Huang et al. This work is published and licensed by Dove Medical Press Limited The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.
spellingShingle Original Research
Huang, Xiaojun
Deng, Zhaomin
Zhang, Qiang
Li, Wanyi
Wang, Baoning
Li, Mingyuan
Relationship between the iceA gene of Helicobacter pylori and clinical outcomes
title Relationship between the iceA gene of Helicobacter pylori and clinical outcomes
title_full Relationship between the iceA gene of Helicobacter pylori and clinical outcomes
title_fullStr Relationship between the iceA gene of Helicobacter pylori and clinical outcomes
title_full_unstemmed Relationship between the iceA gene of Helicobacter pylori and clinical outcomes
title_short Relationship between the iceA gene of Helicobacter pylori and clinical outcomes
title_sort relationship between the icea gene of helicobacter pylori and clinical outcomes
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4939977/
https://www.ncbi.nlm.nih.gov/pubmed/27462162
http://dx.doi.org/10.2147/TCRM.S107991
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