Time-resolved studies define the nature of toxic IAPP intermediates, providing insight for anti-amyloidosis therapeutics

Islet amyloidosis by IAPP contributes to pancreatic β-cell death in diabetes, but the nature of toxic IAPP species remains elusive. Using concurrent time-resolved biophysical and biological measurements, we define the toxic species produced during IAPP amyloid formation and link their properties to...

Descripción completa

Detalles Bibliográficos
Autores principales: Abedini, Andisheh, Plesner, Annette, Cao, Ping, Ridgway, Zachary, Zhang, Jinghua, Tu, Ling-Hsien, Middleton, Chris T, Chao, Brian, Sartori, Daniel J, Meng, Fanling, Wang, Hui, Wong, Amy G, Zanni, Martin T, Verchere, C Bruce, Raleigh, Daniel P, Schmidt, Ann Marie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2016
Materias:
Biochemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4940161/
https://www.ncbi.nlm.nih.gov/pubmed/27213520
http://dx.doi.org/10.7554/eLife.12977

Ejemplares similares

Ejemplares similares