Inclusion of Strep-Tag II in design of antigen receptors for T cell immunotherapy

The tactical introduction of Strep-tag II into synthetic antigen receptors provides engineered T cells with a marker for identification and rapid purification, and a functional element for selective antibody coated microbead-driven large-scale expansion. Such receptor designs can be applied to chime...

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Detalles Bibliográficos
Autores principales: Liu, Lingfeng, Sommermeyer, Daniel, Cabanov, Alexandra, Kosasih, Paula, Hill, Tyler, Riddell, Stanley R
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4940167/
https://www.ncbi.nlm.nih.gov/pubmed/26900664
http://dx.doi.org/10.1038/nbt.3461
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author Liu, Lingfeng
Sommermeyer, Daniel
Cabanov, Alexandra
Kosasih, Paula
Hill, Tyler
Riddell, Stanley R
author_facet Liu, Lingfeng
Sommermeyer, Daniel
Cabanov, Alexandra
Kosasih, Paula
Hill, Tyler
Riddell, Stanley R
author_sort Liu, Lingfeng
collection PubMed
description The tactical introduction of Strep-tag II into synthetic antigen receptors provides engineered T cells with a marker for identification and rapid purification, and a functional element for selective antibody coated microbead-driven large-scale expansion. Such receptor designs can be applied to chimeric antigen receptors of different ligand specificities and costimulatory domains, and to T cell receptors to facilitate cGMP manufacturing of adoptive T cell therapies to treat cancer and other diseases.
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spelling pubmed-49401672016-08-22 Inclusion of Strep-Tag II in design of antigen receptors for T cell immunotherapy Liu, Lingfeng Sommermeyer, Daniel Cabanov, Alexandra Kosasih, Paula Hill, Tyler Riddell, Stanley R Nat Biotechnol Article The tactical introduction of Strep-tag II into synthetic antigen receptors provides engineered T cells with a marker for identification and rapid purification, and a functional element for selective antibody coated microbead-driven large-scale expansion. Such receptor designs can be applied to chimeric antigen receptors of different ligand specificities and costimulatory domains, and to T cell receptors to facilitate cGMP manufacturing of adoptive T cell therapies to treat cancer and other diseases. 2016-02-22 2016-04 /pmc/articles/PMC4940167/ /pubmed/26900664 http://dx.doi.org/10.1038/nbt.3461 Text en Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use: http://www.nature.com/authors/editorial_policies/license.html#terms
spellingShingle Article
Liu, Lingfeng
Sommermeyer, Daniel
Cabanov, Alexandra
Kosasih, Paula
Hill, Tyler
Riddell, Stanley R
Inclusion of Strep-Tag II in design of antigen receptors for T cell immunotherapy
title Inclusion of Strep-Tag II in design of antigen receptors for T cell immunotherapy
title_full Inclusion of Strep-Tag II in design of antigen receptors for T cell immunotherapy
title_fullStr Inclusion of Strep-Tag II in design of antigen receptors for T cell immunotherapy
title_full_unstemmed Inclusion of Strep-Tag II in design of antigen receptors for T cell immunotherapy
title_short Inclusion of Strep-Tag II in design of antigen receptors for T cell immunotherapy
title_sort inclusion of strep-tag ii in design of antigen receptors for t cell immunotherapy
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4940167/
https://www.ncbi.nlm.nih.gov/pubmed/26900664
http://dx.doi.org/10.1038/nbt.3461
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