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Phytochemical Analysis and Antifungal Activity of Extracts from Leaves and Fruit Residues of Brazilian Savanna Plants Aiming Its Use as Safe Fungicides
ABSTRACT: The increasing demand for safe food without preservatives or pesticides residues has encouraged several studies on natural products with antifungal activity and low toxicity. In this study, ethanolic extracts from leaves and fruit residues (peel and seeds) of three Brazilian savanna specie...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Berlin Heidelberg
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4940252/ https://www.ncbi.nlm.nih.gov/pubmed/27169570 http://dx.doi.org/10.1007/s13659-016-0101-y |
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author | Breda, Caroline Alves Gasperini, Alessandra Marcon Garcia, Vera Lucia Monteiro, Karin Maia Bataglion, Giovana Anceski Eberlin, Marcos Nogueira Duarte, Marta Cristina Teixeira |
author_facet | Breda, Caroline Alves Gasperini, Alessandra Marcon Garcia, Vera Lucia Monteiro, Karin Maia Bataglion, Giovana Anceski Eberlin, Marcos Nogueira Duarte, Marta Cristina Teixeira |
author_sort | Breda, Caroline Alves |
collection | PubMed |
description | ABSTRACT: The increasing demand for safe food without preservatives or pesticides residues has encouraged several studies on natural products with antifungal activity and low toxicity. In this study, ethanolic extracts from leaves and fruit residues (peel and seeds) of three Brazilian savanna species (Acrocomia aculeata, Campomanesia adamantium and Caryocar brasiliense) were evaluated against phytopathogenic fungi. Additionally, the most active extract was chemically characterized by ESI-MS and its oral acute toxicity was evaluated. Extracts from C. brasiliense (pequi) peel and leaves were active against Alternaria alternata, Alternaria solani and Venturia pirina with minimal inhibitory concentrations between 350 and 1000 µg/mL. When incorporated in solid media, these extracts extended the lag phase of A. alternata and A. solani and reduced the growth rate of A. solani. Pequi peel extract showed better antifungal activity and their ESI-MS analysis revealed the presence of substances widely reported as antifungal such as gallic acid, quinic acid, ellagic acid, glucogalin and corilagin. The oral acute toxicity was relatively low, being considered safe for use as a potential natural fungicide. GRAPHICAL ABSTRACT: [Image: see text] |
format | Online Article Text |
id | pubmed-4940252 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Springer Berlin Heidelberg |
record_format | MEDLINE/PubMed |
spelling | pubmed-49402522016-07-21 Phytochemical Analysis and Antifungal Activity of Extracts from Leaves and Fruit Residues of Brazilian Savanna Plants Aiming Its Use as Safe Fungicides Breda, Caroline Alves Gasperini, Alessandra Marcon Garcia, Vera Lucia Monteiro, Karin Maia Bataglion, Giovana Anceski Eberlin, Marcos Nogueira Duarte, Marta Cristina Teixeira Nat Prod Bioprospect Original Article ABSTRACT: The increasing demand for safe food without preservatives or pesticides residues has encouraged several studies on natural products with antifungal activity and low toxicity. In this study, ethanolic extracts from leaves and fruit residues (peel and seeds) of three Brazilian savanna species (Acrocomia aculeata, Campomanesia adamantium and Caryocar brasiliense) were evaluated against phytopathogenic fungi. Additionally, the most active extract was chemically characterized by ESI-MS and its oral acute toxicity was evaluated. Extracts from C. brasiliense (pequi) peel and leaves were active against Alternaria alternata, Alternaria solani and Venturia pirina with minimal inhibitory concentrations between 350 and 1000 µg/mL. When incorporated in solid media, these extracts extended the lag phase of A. alternata and A. solani and reduced the growth rate of A. solani. Pequi peel extract showed better antifungal activity and their ESI-MS analysis revealed the presence of substances widely reported as antifungal such as gallic acid, quinic acid, ellagic acid, glucogalin and corilagin. The oral acute toxicity was relatively low, being considered safe for use as a potential natural fungicide. GRAPHICAL ABSTRACT: [Image: see text] Springer Berlin Heidelberg 2016-05-11 /pmc/articles/PMC4940252/ /pubmed/27169570 http://dx.doi.org/10.1007/s13659-016-0101-y Text en © The Author(s) 2016 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. |
spellingShingle | Original Article Breda, Caroline Alves Gasperini, Alessandra Marcon Garcia, Vera Lucia Monteiro, Karin Maia Bataglion, Giovana Anceski Eberlin, Marcos Nogueira Duarte, Marta Cristina Teixeira Phytochemical Analysis and Antifungal Activity of Extracts from Leaves and Fruit Residues of Brazilian Savanna Plants Aiming Its Use as Safe Fungicides |
title | Phytochemical Analysis and Antifungal Activity of Extracts from Leaves and Fruit Residues of Brazilian Savanna Plants Aiming Its Use as Safe Fungicides |
title_full | Phytochemical Analysis and Antifungal Activity of Extracts from Leaves and Fruit Residues of Brazilian Savanna Plants Aiming Its Use as Safe Fungicides |
title_fullStr | Phytochemical Analysis and Antifungal Activity of Extracts from Leaves and Fruit Residues of Brazilian Savanna Plants Aiming Its Use as Safe Fungicides |
title_full_unstemmed | Phytochemical Analysis and Antifungal Activity of Extracts from Leaves and Fruit Residues of Brazilian Savanna Plants Aiming Its Use as Safe Fungicides |
title_short | Phytochemical Analysis and Antifungal Activity of Extracts from Leaves and Fruit Residues of Brazilian Savanna Plants Aiming Its Use as Safe Fungicides |
title_sort | phytochemical analysis and antifungal activity of extracts from leaves and fruit residues of brazilian savanna plants aiming its use as safe fungicides |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4940252/ https://www.ncbi.nlm.nih.gov/pubmed/27169570 http://dx.doi.org/10.1007/s13659-016-0101-y |
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