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Adeno-Associated Virus 2-Mediated Hepatocellular Carcinoma is Very Rare in Korean Patients
BACKGROUND: The incidence and etiology of hepatocellular carcinoma (HCC) vary widely according to race and geographic regions. The insertional mutagenesis of adeno-associated virus 2 (AAV2) has recently been considered a new viral etiology of HCC. The aim of this study was to investigate the frequen...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Korean Society for Laboratory Medicine
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4940491/ https://www.ncbi.nlm.nih.gov/pubmed/27374713 http://dx.doi.org/10.3343/alm.2016.36.5.469 |
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author | Park, Kyoung-Jin Lee, Jongan Park, June-Hee Joh, Jae-Won Kwon, Choon Hyuck David Kim, Jong-Won |
author_facet | Park, Kyoung-Jin Lee, Jongan Park, June-Hee Joh, Jae-Won Kwon, Choon Hyuck David Kim, Jong-Won |
author_sort | Park, Kyoung-Jin |
collection | PubMed |
description | BACKGROUND: The incidence and etiology of hepatocellular carcinoma (HCC) vary widely according to race and geographic regions. The insertional mutagenesis of adeno-associated virus 2 (AAV2) has recently been considered a new viral etiology of HCC. The aim of this study was to investigate the frequency and clinical characteristics of AAV2 in Korean patients with HCC. METHODS: A total of 289 unrelated Korean patients with HCC, including 159 Hepatitis-B-related cases, 16 Hepatitis-C-related cases, and 114 viral serology-negative cases, who underwent surgery at the Samsung Medical Center in Korea from 2009 to 2014 were enrolled in this study. The presence of AAV2 in fresh-frozen tumor tissues was investigated by DNA PCR and Sanger sequencing. The clinical and pathological characteristics of AAV2-associated HCC in these patients were compared with previous findings in French patients. RESULTS: The AAV2 detection rate in Korean patients (2/289) was very low compared with that in French patients (11/193). Similar to the French patients, the Korean patients with AAV2-related HCC showed no signs of liver cirrhosis. The Korean patients were younger than the French patients with the same AAV2-associated HCC; the ages at diagnosis of the two Korean patients were 47 and 39 yr, while the median age of the 11 French patients was 55 yr (range 43-90 yr). CONCLUSIONS: AAV2-associated HCC was very rare in Korean patients with HCC. Despite a limited number of cases, this study is the first to report the clinical characteristics of Korean patients with AAV2-associated HCC. These findings suggest epidemiologic differences in viral hepatocarcinogenesis between Korean and European patients. |
format | Online Article Text |
id | pubmed-4940491 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | The Korean Society for Laboratory Medicine |
record_format | MEDLINE/PubMed |
spelling | pubmed-49404912016-09-01 Adeno-Associated Virus 2-Mediated Hepatocellular Carcinoma is Very Rare in Korean Patients Park, Kyoung-Jin Lee, Jongan Park, June-Hee Joh, Jae-Won Kwon, Choon Hyuck David Kim, Jong-Won Ann Lab Med Original Article BACKGROUND: The incidence and etiology of hepatocellular carcinoma (HCC) vary widely according to race and geographic regions. The insertional mutagenesis of adeno-associated virus 2 (AAV2) has recently been considered a new viral etiology of HCC. The aim of this study was to investigate the frequency and clinical characteristics of AAV2 in Korean patients with HCC. METHODS: A total of 289 unrelated Korean patients with HCC, including 159 Hepatitis-B-related cases, 16 Hepatitis-C-related cases, and 114 viral serology-negative cases, who underwent surgery at the Samsung Medical Center in Korea from 2009 to 2014 were enrolled in this study. The presence of AAV2 in fresh-frozen tumor tissues was investigated by DNA PCR and Sanger sequencing. The clinical and pathological characteristics of AAV2-associated HCC in these patients were compared with previous findings in French patients. RESULTS: The AAV2 detection rate in Korean patients (2/289) was very low compared with that in French patients (11/193). Similar to the French patients, the Korean patients with AAV2-related HCC showed no signs of liver cirrhosis. The Korean patients were younger than the French patients with the same AAV2-associated HCC; the ages at diagnosis of the two Korean patients were 47 and 39 yr, while the median age of the 11 French patients was 55 yr (range 43-90 yr). CONCLUSIONS: AAV2-associated HCC was very rare in Korean patients with HCC. Despite a limited number of cases, this study is the first to report the clinical characteristics of Korean patients with AAV2-associated HCC. These findings suggest epidemiologic differences in viral hepatocarcinogenesis between Korean and European patients. The Korean Society for Laboratory Medicine 2016-09 2016-06-24 /pmc/articles/PMC4940491/ /pubmed/27374713 http://dx.doi.org/10.3343/alm.2016.36.5.469 Text en © The Korean Society for Laboratory Medicine. http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Park, Kyoung-Jin Lee, Jongan Park, June-Hee Joh, Jae-Won Kwon, Choon Hyuck David Kim, Jong-Won Adeno-Associated Virus 2-Mediated Hepatocellular Carcinoma is Very Rare in Korean Patients |
title | Adeno-Associated Virus 2-Mediated Hepatocellular Carcinoma is Very Rare in Korean Patients |
title_full | Adeno-Associated Virus 2-Mediated Hepatocellular Carcinoma is Very Rare in Korean Patients |
title_fullStr | Adeno-Associated Virus 2-Mediated Hepatocellular Carcinoma is Very Rare in Korean Patients |
title_full_unstemmed | Adeno-Associated Virus 2-Mediated Hepatocellular Carcinoma is Very Rare in Korean Patients |
title_short | Adeno-Associated Virus 2-Mediated Hepatocellular Carcinoma is Very Rare in Korean Patients |
title_sort | adeno-associated virus 2-mediated hepatocellular carcinoma is very rare in korean patients |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4940491/ https://www.ncbi.nlm.nih.gov/pubmed/27374713 http://dx.doi.org/10.3343/alm.2016.36.5.469 |
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