Loxapine and Cyproheptadine Combined Limit Clozapine Rebound Psychosis and May Also Predict Clozapine Response

Clozapine has been consistently shown to be superior to other antipsychotics in the treatment of psychosis. However, clozapine usage has been limited due to required routine blood monitoring and the potential for life threatening side effects. We report a case of a 66-year-old female patient, who de...

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Detalles Bibliográficos
Autores principales: Aboueid, Lila, McCarthy, Richard H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2016
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4940529/
https://www.ncbi.nlm.nih.gov/pubmed/27433365
http://dx.doi.org/10.1155/2016/6123913
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author Aboueid, Lila
McCarthy, Richard H.
author_facet Aboueid, Lila
McCarthy, Richard H.
author_sort Aboueid, Lila
collection PubMed
description Clozapine has been consistently shown to be superior to other antipsychotics in the treatment of psychosis. However, clozapine usage has been limited due to required routine blood monitoring and the potential for life threatening side effects. We report a case of a 66-year-old female patient, who developed clozapine-induced agranulocytosis after 10 weeks of clozapine treatment and was subsequently successfully treated with a combination of loxapine and cyproheptadine. The combination is thought to mimic the pharmacological profile of clozapine, rendering it as a possible alternative to traditional clozapine treatment.
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spelling pubmed-49405292016-07-18 Loxapine and Cyproheptadine Combined Limit Clozapine Rebound Psychosis and May Also Predict Clozapine Response Aboueid, Lila McCarthy, Richard H. Case Rep Psychiatry Case Report Clozapine has been consistently shown to be superior to other antipsychotics in the treatment of psychosis. However, clozapine usage has been limited due to required routine blood monitoring and the potential for life threatening side effects. We report a case of a 66-year-old female patient, who developed clozapine-induced agranulocytosis after 10 weeks of clozapine treatment and was subsequently successfully treated with a combination of loxapine and cyproheptadine. The combination is thought to mimic the pharmacological profile of clozapine, rendering it as a possible alternative to traditional clozapine treatment. Hindawi Publishing Corporation 2016 2016-06-28 /pmc/articles/PMC4940529/ /pubmed/27433365 http://dx.doi.org/10.1155/2016/6123913 Text en Copyright © 2016 L. Aboueid and R. H. McCarthy. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Aboueid, Lila
McCarthy, Richard H.
Loxapine and Cyproheptadine Combined Limit Clozapine Rebound Psychosis and May Also Predict Clozapine Response
title Loxapine and Cyproheptadine Combined Limit Clozapine Rebound Psychosis and May Also Predict Clozapine Response
title_full Loxapine and Cyproheptadine Combined Limit Clozapine Rebound Psychosis and May Also Predict Clozapine Response
title_fullStr Loxapine and Cyproheptadine Combined Limit Clozapine Rebound Psychosis and May Also Predict Clozapine Response
title_full_unstemmed Loxapine and Cyproheptadine Combined Limit Clozapine Rebound Psychosis and May Also Predict Clozapine Response
title_short Loxapine and Cyproheptadine Combined Limit Clozapine Rebound Psychosis and May Also Predict Clozapine Response
title_sort loxapine and cyproheptadine combined limit clozapine rebound psychosis and may also predict clozapine response
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4940529/
https://www.ncbi.nlm.nih.gov/pubmed/27433365
http://dx.doi.org/10.1155/2016/6123913
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