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The Association between ESR and CRP and Systemic Hypertension in Sarcoidosis

Introduction. The association between the level of systemic inflammation and systemic hypertension (sHTN) among subjects with sarcoidosis has not been previously explored. Methods. A retrospective study was conducted to investigate the relation between the level of systemic inflammation in sarcoidos...

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Autores principales: Mirsaeidi, Mehdi, Omar, Hesham R., Ebrahimi, Golnaz, Campos, Micheal
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4940541/
https://www.ncbi.nlm.nih.gov/pubmed/27433355
http://dx.doi.org/10.1155/2016/2402515
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author Mirsaeidi, Mehdi
Omar, Hesham R.
Ebrahimi, Golnaz
Campos, Micheal
author_facet Mirsaeidi, Mehdi
Omar, Hesham R.
Ebrahimi, Golnaz
Campos, Micheal
author_sort Mirsaeidi, Mehdi
collection PubMed
description Introduction. The association between the level of systemic inflammation and systemic hypertension (sHTN) among subjects with sarcoidosis has not been previously explored. Methods. A retrospective study was conducted to investigate the relation between the level of systemic inflammation in sarcoidosis, measured by various serum inflammatory markers, and sHTN. Results. Among a total of 108 cases with sarcoidosis (mean age: 53.4 years, 76.9% females), 55 (50.9%) had sHTN and 53 (49.1%) were normotensive. ESR was highly associated with sHTN. The patients with sHTN had higher mean ESR levels compared with normotensives (48.8 ± 35 versus 23.2 ± 27 mm/hr, resp.; P = 0.001). ROC curve analysis for ESR revealed an AUC value of 0.795 (95% CI: 0.692–0.897; P = 0.0001). With regard to CRP, there was a trend towards higher mean values in sHTN group (3.4 versus 1.7 mg/L; P = 0.067) and significantly higher prevalence of sHTN in the highest CRP quartile compared to the lowest one (69.6% versus 30%; OR 4.95; P = 0.017). ROC curve analysis for CRP revealed an AUC value of 0.644 (95% CI: 0.518–0.769; P = 0.03). On multivariate analysis, ESR and the CRP remained independent predictors for sHTN among subjects with sarcoidosis. Conclusion. Systemic inflammation is associated with the presence of sHTN in sarcoidosis.
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spelling pubmed-49405412016-07-18 The Association between ESR and CRP and Systemic Hypertension in Sarcoidosis Mirsaeidi, Mehdi Omar, Hesham R. Ebrahimi, Golnaz Campos, Micheal Int J Hypertens Research Article Introduction. The association between the level of systemic inflammation and systemic hypertension (sHTN) among subjects with sarcoidosis has not been previously explored. Methods. A retrospective study was conducted to investigate the relation between the level of systemic inflammation in sarcoidosis, measured by various serum inflammatory markers, and sHTN. Results. Among a total of 108 cases with sarcoidosis (mean age: 53.4 years, 76.9% females), 55 (50.9%) had sHTN and 53 (49.1%) were normotensive. ESR was highly associated with sHTN. The patients with sHTN had higher mean ESR levels compared with normotensives (48.8 ± 35 versus 23.2 ± 27 mm/hr, resp.; P = 0.001). ROC curve analysis for ESR revealed an AUC value of 0.795 (95% CI: 0.692–0.897; P = 0.0001). With regard to CRP, there was a trend towards higher mean values in sHTN group (3.4 versus 1.7 mg/L; P = 0.067) and significantly higher prevalence of sHTN in the highest CRP quartile compared to the lowest one (69.6% versus 30%; OR 4.95; P = 0.017). ROC curve analysis for CRP revealed an AUC value of 0.644 (95% CI: 0.518–0.769; P = 0.03). On multivariate analysis, ESR and the CRP remained independent predictors for sHTN among subjects with sarcoidosis. Conclusion. Systemic inflammation is associated with the presence of sHTN in sarcoidosis. Hindawi Publishing Corporation 2016 2016-06-28 /pmc/articles/PMC4940541/ /pubmed/27433355 http://dx.doi.org/10.1155/2016/2402515 Text en Copyright © 2016 Mehdi Mirsaeidi et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Mirsaeidi, Mehdi
Omar, Hesham R.
Ebrahimi, Golnaz
Campos, Micheal
The Association between ESR and CRP and Systemic Hypertension in Sarcoidosis
title The Association between ESR and CRP and Systemic Hypertension in Sarcoidosis
title_full The Association between ESR and CRP and Systemic Hypertension in Sarcoidosis
title_fullStr The Association between ESR and CRP and Systemic Hypertension in Sarcoidosis
title_full_unstemmed The Association between ESR and CRP and Systemic Hypertension in Sarcoidosis
title_short The Association between ESR and CRP and Systemic Hypertension in Sarcoidosis
title_sort association between esr and crp and systemic hypertension in sarcoidosis
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4940541/
https://www.ncbi.nlm.nih.gov/pubmed/27433355
http://dx.doi.org/10.1155/2016/2402515
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