Cargando…
The Association between ESR and CRP and Systemic Hypertension in Sarcoidosis
Introduction. The association between the level of systemic inflammation and systemic hypertension (sHTN) among subjects with sarcoidosis has not been previously explored. Methods. A retrospective study was conducted to investigate the relation between the level of systemic inflammation in sarcoidos...
Autores principales: | , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2016
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4940541/ https://www.ncbi.nlm.nih.gov/pubmed/27433355 http://dx.doi.org/10.1155/2016/2402515 |
_version_ | 1782442162310348800 |
---|---|
author | Mirsaeidi, Mehdi Omar, Hesham R. Ebrahimi, Golnaz Campos, Micheal |
author_facet | Mirsaeidi, Mehdi Omar, Hesham R. Ebrahimi, Golnaz Campos, Micheal |
author_sort | Mirsaeidi, Mehdi |
collection | PubMed |
description | Introduction. The association between the level of systemic inflammation and systemic hypertension (sHTN) among subjects with sarcoidosis has not been previously explored. Methods. A retrospective study was conducted to investigate the relation between the level of systemic inflammation in sarcoidosis, measured by various serum inflammatory markers, and sHTN. Results. Among a total of 108 cases with sarcoidosis (mean age: 53.4 years, 76.9% females), 55 (50.9%) had sHTN and 53 (49.1%) were normotensive. ESR was highly associated with sHTN. The patients with sHTN had higher mean ESR levels compared with normotensives (48.8 ± 35 versus 23.2 ± 27 mm/hr, resp.; P = 0.001). ROC curve analysis for ESR revealed an AUC value of 0.795 (95% CI: 0.692–0.897; P = 0.0001). With regard to CRP, there was a trend towards higher mean values in sHTN group (3.4 versus 1.7 mg/L; P = 0.067) and significantly higher prevalence of sHTN in the highest CRP quartile compared to the lowest one (69.6% versus 30%; OR 4.95; P = 0.017). ROC curve analysis for CRP revealed an AUC value of 0.644 (95% CI: 0.518–0.769; P = 0.03). On multivariate analysis, ESR and the CRP remained independent predictors for sHTN among subjects with sarcoidosis. Conclusion. Systemic inflammation is associated with the presence of sHTN in sarcoidosis. |
format | Online Article Text |
id | pubmed-4940541 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-49405412016-07-18 The Association between ESR and CRP and Systemic Hypertension in Sarcoidosis Mirsaeidi, Mehdi Omar, Hesham R. Ebrahimi, Golnaz Campos, Micheal Int J Hypertens Research Article Introduction. The association between the level of systemic inflammation and systemic hypertension (sHTN) among subjects with sarcoidosis has not been previously explored. Methods. A retrospective study was conducted to investigate the relation between the level of systemic inflammation in sarcoidosis, measured by various serum inflammatory markers, and sHTN. Results. Among a total of 108 cases with sarcoidosis (mean age: 53.4 years, 76.9% females), 55 (50.9%) had sHTN and 53 (49.1%) were normotensive. ESR was highly associated with sHTN. The patients with sHTN had higher mean ESR levels compared with normotensives (48.8 ± 35 versus 23.2 ± 27 mm/hr, resp.; P = 0.001). ROC curve analysis for ESR revealed an AUC value of 0.795 (95% CI: 0.692–0.897; P = 0.0001). With regard to CRP, there was a trend towards higher mean values in sHTN group (3.4 versus 1.7 mg/L; P = 0.067) and significantly higher prevalence of sHTN in the highest CRP quartile compared to the lowest one (69.6% versus 30%; OR 4.95; P = 0.017). ROC curve analysis for CRP revealed an AUC value of 0.644 (95% CI: 0.518–0.769; P = 0.03). On multivariate analysis, ESR and the CRP remained independent predictors for sHTN among subjects with sarcoidosis. Conclusion. Systemic inflammation is associated with the presence of sHTN in sarcoidosis. Hindawi Publishing Corporation 2016 2016-06-28 /pmc/articles/PMC4940541/ /pubmed/27433355 http://dx.doi.org/10.1155/2016/2402515 Text en Copyright © 2016 Mehdi Mirsaeidi et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Mirsaeidi, Mehdi Omar, Hesham R. Ebrahimi, Golnaz Campos, Micheal The Association between ESR and CRP and Systemic Hypertension in Sarcoidosis |
title | The Association between ESR and CRP and Systemic Hypertension in Sarcoidosis |
title_full | The Association between ESR and CRP and Systemic Hypertension in Sarcoidosis |
title_fullStr | The Association between ESR and CRP and Systemic Hypertension in Sarcoidosis |
title_full_unstemmed | The Association between ESR and CRP and Systemic Hypertension in Sarcoidosis |
title_short | The Association between ESR and CRP and Systemic Hypertension in Sarcoidosis |
title_sort | association between esr and crp and systemic hypertension in sarcoidosis |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4940541/ https://www.ncbi.nlm.nih.gov/pubmed/27433355 http://dx.doi.org/10.1155/2016/2402515 |
work_keys_str_mv | AT mirsaeidimehdi theassociationbetweenesrandcrpandsystemichypertensioninsarcoidosis AT omarheshamr theassociationbetweenesrandcrpandsystemichypertensioninsarcoidosis AT ebrahimigolnaz theassociationbetweenesrandcrpandsystemichypertensioninsarcoidosis AT camposmicheal theassociationbetweenesrandcrpandsystemichypertensioninsarcoidosis AT mirsaeidimehdi associationbetweenesrandcrpandsystemichypertensioninsarcoidosis AT omarheshamr associationbetweenesrandcrpandsystemichypertensioninsarcoidosis AT ebrahimigolnaz associationbetweenesrandcrpandsystemichypertensioninsarcoidosis AT camposmicheal associationbetweenesrandcrpandsystemichypertensioninsarcoidosis |