Transcription Factor EB Is Selectively Reduced in the Nuclear Fractions of Alzheimer's and Amyotrophic Lateral Sclerosis Brains

Multiple studies suggest that autophagy is strongly dysregulated in Alzheimer's disease (AD) and amyotrophic lateral sclerosis (ALS), as evidenced by accumulation of numerous autophagosomes, lysosomes with discontinuous membranes, and aggregated proteins in the patients' brains. Transcript...

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Detalles Bibliográficos
Autores principales: Wang, Hongjie, Wang, Ruizhi, Xu, Shaohua, Lakshmana, Madepalli K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4940567/
https://www.ncbi.nlm.nih.gov/pubmed/27433468
http://dx.doi.org/10.1155/2016/4732837

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