Cargando…

Morbidity assessment of Opisthorchis viverrini infection in rural Laos: I. Parasitological, clinical, ultrasonographical and biochemical findings

BACKGROUND: Infections with the food-borne trematode Opisthorchis viverinni are common in Southeast Asia. In Lao PDR alone, two million people are supposed to be infected. Opisthorchiasis may cause severe liver disease, eventually leading to cholangiocarcinoma. The objective of this study is to asse...

Descripción completa

Detalles Bibliográficos
Autores principales: Feldmeier, Hermann, Hazay, Miklos, Sato, Megumi, Tiengkham, Pongvongsa, Nishimoto, Futoshi, Jiang, Hongwei, Sopraseuth, Vatsana, Moji, Kazuhiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4940689/
https://www.ncbi.nlm.nih.gov/pubmed/27433131
http://dx.doi.org/10.1186/s41182-016-0012-y
_version_ 1782442180725440512
author Feldmeier, Hermann
Hazay, Miklos
Sato, Megumi
Tiengkham, Pongvongsa
Nishimoto, Futoshi
Jiang, Hongwei
Sopraseuth, Vatsana
Moji, Kazuhiko
author_facet Feldmeier, Hermann
Hazay, Miklos
Sato, Megumi
Tiengkham, Pongvongsa
Nishimoto, Futoshi
Jiang, Hongwei
Sopraseuth, Vatsana
Moji, Kazuhiko
author_sort Feldmeier, Hermann
collection PubMed
description BACKGROUND: Infections with the food-borne trematode Opisthorchis viverinni are common in Southeast Asia. In Lao PDR alone, two million people are supposed to be infected. Opisthorchiasis may cause severe liver disease, eventually leading to cholangiocarcinoma. The objective of this study is to assess the eating habits, complaints, symptoms, signs and ultrasonographical findings in three different areas of Savannakhet Province. METHODS: Study participants were recruited in Lahanam village in the flood-prone lowland of, Sonkhone district, Savannakhet Province (group A); in Non Somboon village, a community located on a hilly plateau in the same district (group B); and in staff of Savannakhet Province Hospital, Savannakhet town (group C). Eating habits, complaints and symptoms were recorded by standardized structured questionnaires. Participants were thoroughly examined clinically, and ultrasonography was performed. O. viverrini eggs were looked for in stool and in duodenal fluid. An array of biochemical and haematological parameters potentially related to liver disease was determined. Group A consisted of 45, group B of 31 and group C of 18 individuals. RESULTS: Eating habits were similar in the three groups, except that participants from group C tended to consume less high-risk types of fish dishes and more frequently ate beef and pork. Average intensity of infection (eggs per gram of stool) was low, but significantly higher in group A than in group B and C (p < 0.001). Medical history and complaints were similar in the three groups. Ultrasonography did not reveal any bile duct pathology. The only pathological finding was a slight elevation of ASAT and gamma-GT in a few participants in groups A and B. CONCLUSIONS: The study shows that eating habits favouring the infection with O. viverrini are common in south Laos. Although the average intensity of infection was low, there was a significant difference between the groups, paralleling slightly different eating habits. Clinically, this corresponded to a paucity of liver disease-associated complaints and signs. The low intensity of infection probably explains why no alterations of bile ducts were detectable by ultrasonography.
format Online
Article
Text
id pubmed-4940689
institution National Center for Biotechnology Information
language English
publishDate 2016
publisher BioMed Central
record_format MEDLINE/PubMed
spelling pubmed-49406892016-07-18 Morbidity assessment of Opisthorchis viverrini infection in rural Laos: I. Parasitological, clinical, ultrasonographical and biochemical findings Feldmeier, Hermann Hazay, Miklos Sato, Megumi Tiengkham, Pongvongsa Nishimoto, Futoshi Jiang, Hongwei Sopraseuth, Vatsana Moji, Kazuhiko Trop Med Health Research BACKGROUND: Infections with the food-borne trematode Opisthorchis viverinni are common in Southeast Asia. In Lao PDR alone, two million people are supposed to be infected. Opisthorchiasis may cause severe liver disease, eventually leading to cholangiocarcinoma. The objective of this study is to assess the eating habits, complaints, symptoms, signs and ultrasonographical findings in three different areas of Savannakhet Province. METHODS: Study participants were recruited in Lahanam village in the flood-prone lowland of, Sonkhone district, Savannakhet Province (group A); in Non Somboon village, a community located on a hilly plateau in the same district (group B); and in staff of Savannakhet Province Hospital, Savannakhet town (group C). Eating habits, complaints and symptoms were recorded by standardized structured questionnaires. Participants were thoroughly examined clinically, and ultrasonography was performed. O. viverrini eggs were looked for in stool and in duodenal fluid. An array of biochemical and haematological parameters potentially related to liver disease was determined. Group A consisted of 45, group B of 31 and group C of 18 individuals. RESULTS: Eating habits were similar in the three groups, except that participants from group C tended to consume less high-risk types of fish dishes and more frequently ate beef and pork. Average intensity of infection (eggs per gram of stool) was low, but significantly higher in group A than in group B and C (p < 0.001). Medical history and complaints were similar in the three groups. Ultrasonography did not reveal any bile duct pathology. The only pathological finding was a slight elevation of ASAT and gamma-GT in a few participants in groups A and B. CONCLUSIONS: The study shows that eating habits favouring the infection with O. viverrini are common in south Laos. Although the average intensity of infection was low, there was a significant difference between the groups, paralleling slightly different eating habits. Clinically, this corresponded to a paucity of liver disease-associated complaints and signs. The low intensity of infection probably explains why no alterations of bile ducts were detectable by ultrasonography. BioMed Central 2016-05-16 /pmc/articles/PMC4940689/ /pubmed/27433131 http://dx.doi.org/10.1186/s41182-016-0012-y Text en © The Author(s) 2016 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research
Feldmeier, Hermann
Hazay, Miklos
Sato, Megumi
Tiengkham, Pongvongsa
Nishimoto, Futoshi
Jiang, Hongwei
Sopraseuth, Vatsana
Moji, Kazuhiko
Morbidity assessment of Opisthorchis viverrini infection in rural Laos: I. Parasitological, clinical, ultrasonographical and biochemical findings
title Morbidity assessment of Opisthorchis viverrini infection in rural Laos: I. Parasitological, clinical, ultrasonographical and biochemical findings
title_full Morbidity assessment of Opisthorchis viverrini infection in rural Laos: I. Parasitological, clinical, ultrasonographical and biochemical findings
title_fullStr Morbidity assessment of Opisthorchis viverrini infection in rural Laos: I. Parasitological, clinical, ultrasonographical and biochemical findings
title_full_unstemmed Morbidity assessment of Opisthorchis viverrini infection in rural Laos: I. Parasitological, clinical, ultrasonographical and biochemical findings
title_short Morbidity assessment of Opisthorchis viverrini infection in rural Laos: I. Parasitological, clinical, ultrasonographical and biochemical findings
title_sort morbidity assessment of opisthorchis viverrini infection in rural laos: i. parasitological, clinical, ultrasonographical and biochemical findings
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4940689/
https://www.ncbi.nlm.nih.gov/pubmed/27433131
http://dx.doi.org/10.1186/s41182-016-0012-y
work_keys_str_mv AT feldmeierhermann morbidityassessmentofopisthorchisviverriniinfectioninrurallaosiparasitologicalclinicalultrasonographicalandbiochemicalfindings
AT hazaymiklos morbidityassessmentofopisthorchisviverriniinfectioninrurallaosiparasitologicalclinicalultrasonographicalandbiochemicalfindings
AT satomegumi morbidityassessmentofopisthorchisviverriniinfectioninrurallaosiparasitologicalclinicalultrasonographicalandbiochemicalfindings
AT tiengkhampongvongsa morbidityassessmentofopisthorchisviverriniinfectioninrurallaosiparasitologicalclinicalultrasonographicalandbiochemicalfindings
AT nishimotofutoshi morbidityassessmentofopisthorchisviverriniinfectioninrurallaosiparasitologicalclinicalultrasonographicalandbiochemicalfindings
AT jianghongwei morbidityassessmentofopisthorchisviverriniinfectioninrurallaosiparasitologicalclinicalultrasonographicalandbiochemicalfindings
AT sopraseuthvatsana morbidityassessmentofopisthorchisviverriniinfectioninrurallaosiparasitologicalclinicalultrasonographicalandbiochemicalfindings
AT mojikazuhiko morbidityassessmentofopisthorchisviverriniinfectioninrurallaosiparasitologicalclinicalultrasonographicalandbiochemicalfindings