Chronic Glutathione Depletion Confers Protection against Alcohol-induced Steatosis: Implication for Redox Activation of AMP-activated Protein Kinase Pathway

The pathogenesis of alcoholic liver disease (ALD) is not well established. However, oxidative stress and associated decreases in levels of glutathione (GSH) are known to play a central role in ALD. The present study examines the effect of GSH deficiency on alcohol-induced liver steatosis in Gclm kno...

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Detalles Bibliográficos
Autores principales: Chen, Ying, Singh, Surendra, Matsumoto, Akiko, Manna, Soumen K., Abdelmegeed, Mohamed A., Golla, Srujana, Murphy, Robert C., Dong, Hongbin, Song, Byoung-Joon, Gonzalez, Frank J., Thompson, David C., Vasiliou, Vasilis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4940737/
https://www.ncbi.nlm.nih.gov/pubmed/27403993
http://dx.doi.org/10.1038/srep29743

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