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Activity of crude extracts from Brazilian cerrado plants against clinically relevant Candida species

BACKGROUND: Medicinal plants have traditionally been used in many parts of the world as alternative medicine. Many extracts and essential oils isolated from plants have disclosed biological activity, justifying the investigation of their potential antimicrobial activity. In this study, the in vitro...

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Autores principales: Correia, Amabel Fernandes, Silveira, Dâmaris, Fonseca-Bazzo, Yris Maria, Magalhães, Pérola Oliveira, Fagg, Christopher William, da Silva, Elton Clementino, Gomes, Suelí Maria, Gandolfi, Lenora, Pratesi, Riccardo, de Medeiros Nóbrega, Yanna Karla
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4940766/
https://www.ncbi.nlm.nih.gov/pubmed/27401815
http://dx.doi.org/10.1186/s12906-016-1164-3
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author Correia, Amabel Fernandes
Silveira, Dâmaris
Fonseca-Bazzo, Yris Maria
Magalhães, Pérola Oliveira
Fagg, Christopher William
da Silva, Elton Clementino
Gomes, Suelí Maria
Gandolfi, Lenora
Pratesi, Riccardo
de Medeiros Nóbrega, Yanna Karla
author_facet Correia, Amabel Fernandes
Silveira, Dâmaris
Fonseca-Bazzo, Yris Maria
Magalhães, Pérola Oliveira
Fagg, Christopher William
da Silva, Elton Clementino
Gomes, Suelí Maria
Gandolfi, Lenora
Pratesi, Riccardo
de Medeiros Nóbrega, Yanna Karla
author_sort Correia, Amabel Fernandes
collection PubMed
description BACKGROUND: Medicinal plants have traditionally been used in many parts of the world as alternative medicine. Many extracts and essential oils isolated from plants have disclosed biological activity, justifying the investigation of their potential antimicrobial activity. In this study, the in vitro antifungal activity of six Brazilian Cerrado medicinal plant species were evaluated against clinically relevant Candida species. METHODS: The crude extract plants were evaluated against American Type Culture Collection (ATCC) standard strains of Candida spp. using disk diffusion method and determining the minimum inhibitory concentration (MIC). The chemical study results were confirmed by HPLC method. RESULTS: All six plant species showed antifungal activity. Among the species studied, Eugenia dysenterica and Pouteria ramiflora showed significant inhibitory activity against C. tropicalis at lowest MIC value of 125 and 500 μg/disc, respectively. The Eugenia dysenterica also disclosed MIC value of 125 μg/disc against C. famata, 250 μg/disc against C. krusei and 500 μg/disc against C. guilliermondii and C. parapsilosis. Pouteria torta, Bauhinia rufa, Erythroxylum daphnites and Erythroxylum subrotundum showed activity against the yeast strains with MIC value of 1000 μg/disc. The chemical study of the most bioactive extracts of Eugenia dysenterica and Pouteria ramiflora revealed catechin derivatives and flavonoids as main components. CONCLUSIONS: All six evaluated plant species showed good antifungal potential against several Candida strains. However, E .dysenterica and P. ramiflora showed the higher inhibitory effect against the non-albicans Candida species. Our results may contribute to the continuing search of new natural occurring products with antifungal activity.
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spelling pubmed-49407662016-07-13 Activity of crude extracts from Brazilian cerrado plants against clinically relevant Candida species Correia, Amabel Fernandes Silveira, Dâmaris Fonseca-Bazzo, Yris Maria Magalhães, Pérola Oliveira Fagg, Christopher William da Silva, Elton Clementino Gomes, Suelí Maria Gandolfi, Lenora Pratesi, Riccardo de Medeiros Nóbrega, Yanna Karla BMC Complement Altern Med Research Article BACKGROUND: Medicinal plants have traditionally been used in many parts of the world as alternative medicine. Many extracts and essential oils isolated from plants have disclosed biological activity, justifying the investigation of their potential antimicrobial activity. In this study, the in vitro antifungal activity of six Brazilian Cerrado medicinal plant species were evaluated against clinically relevant Candida species. METHODS: The crude extract plants were evaluated against American Type Culture Collection (ATCC) standard strains of Candida spp. using disk diffusion method and determining the minimum inhibitory concentration (MIC). The chemical study results were confirmed by HPLC method. RESULTS: All six plant species showed antifungal activity. Among the species studied, Eugenia dysenterica and Pouteria ramiflora showed significant inhibitory activity against C. tropicalis at lowest MIC value of 125 and 500 μg/disc, respectively. The Eugenia dysenterica also disclosed MIC value of 125 μg/disc against C. famata, 250 μg/disc against C. krusei and 500 μg/disc against C. guilliermondii and C. parapsilosis. Pouteria torta, Bauhinia rufa, Erythroxylum daphnites and Erythroxylum subrotundum showed activity against the yeast strains with MIC value of 1000 μg/disc. The chemical study of the most bioactive extracts of Eugenia dysenterica and Pouteria ramiflora revealed catechin derivatives and flavonoids as main components. CONCLUSIONS: All six evaluated plant species showed good antifungal potential against several Candida strains. However, E .dysenterica and P. ramiflora showed the higher inhibitory effect against the non-albicans Candida species. Our results may contribute to the continuing search of new natural occurring products with antifungal activity. BioMed Central 2016-07-11 /pmc/articles/PMC4940766/ /pubmed/27401815 http://dx.doi.org/10.1186/s12906-016-1164-3 Text en © The Author(s). 2016 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Article
Correia, Amabel Fernandes
Silveira, Dâmaris
Fonseca-Bazzo, Yris Maria
Magalhães, Pérola Oliveira
Fagg, Christopher William
da Silva, Elton Clementino
Gomes, Suelí Maria
Gandolfi, Lenora
Pratesi, Riccardo
de Medeiros Nóbrega, Yanna Karla
Activity of crude extracts from Brazilian cerrado plants against clinically relevant Candida species
title Activity of crude extracts from Brazilian cerrado plants against clinically relevant Candida species
title_full Activity of crude extracts from Brazilian cerrado plants against clinically relevant Candida species
title_fullStr Activity of crude extracts from Brazilian cerrado plants against clinically relevant Candida species
title_full_unstemmed Activity of crude extracts from Brazilian cerrado plants against clinically relevant Candida species
title_short Activity of crude extracts from Brazilian cerrado plants against clinically relevant Candida species
title_sort activity of crude extracts from brazilian cerrado plants against clinically relevant candida species
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4940766/
https://www.ncbi.nlm.nih.gov/pubmed/27401815
http://dx.doi.org/10.1186/s12906-016-1164-3
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