Long-term exposure to PGE(2) causes homologous desensitization of receptor-mediated activation of protein kinase A

BACKGROUND: Acute exposure to prostaglandin E(2) (PGE(2)) activates EP receptors in sensory neurons which triggers the cAMP-dependent protein kinase A (PKA) signaling cascade resulting in enhanced excitability of the neurons. With long-term exposure to PGE(2), however, the activation of PKA does not...

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Detalles Bibliográficos
Autores principales: Malty, Ramy Habashy, Hudmon, Andy, Fehrenbacher, Jill C., Vasko, Michael R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4940832/
https://www.ncbi.nlm.nih.gov/pubmed/27400965
http://dx.doi.org/10.1186/s12974-016-0645-0

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