Post-paralysis tyrosine kinase inhibition with masitinib abrogates neuroinflammation and slows disease progression in inherited amyotrophic lateral sclerosis

BACKGROUND: In the SOD1(G93A) mutant rat model of amyotrophic lateral sclerosis (ALS), neuronal death and rapid paralysis progression are associated with the emergence of activated aberrant glial cells that proliferate in the degenerating spinal cord. Whether pharmacological downregulation of such a...

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Detalles Bibliográficos
Autores principales: Trias, Emiliano, Ibarburu, Sofía, Barreto-Núñez, Romina, Babdor, Joël, Maciel, Thiago T., Guillo, Matthias, Gros, Laurent, Dubreuil, Patrice, Díaz-Amarilla, Pablo, Cassina, Patricia, Martínez-Palma, Laura, Moura, Ivan C., Beckman, Joseph S., Hermine, Olivier, Barbeito, Luis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4940876/
https://www.ncbi.nlm.nih.gov/pubmed/27400786
http://dx.doi.org/10.1186/s12974-016-0620-9

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