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The relevance of coagulation factor X protection of adenoviruses in human sera

Intravenous delivery of adenoviruses is the optimal route for many gene therapy applications. Once in the blood, coagulation factor X (FX) binds to the adenovirus capsid and protects the virion from natural antibody and classical complement-mediated neutralisation in mice. However, to date, no studi...

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Detalles Bibliográficos
Autores principales:	Duffy, M R, Doszpoly, A, Turner, G, Nicklin, S A, Baker, A H
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2016
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4940928/ https://www.ncbi.nlm.nih.gov/pubmed/27014840 http://dx.doi.org/10.1038/gt.2016.32

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