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The mixed-lineage kinase 3 inhibitor URMC-099 facilitates microglial amyloid-β degradation

BACKGROUND: Amyloid-β (Aβ)-stimulated microglial inflammatory responses engage mitogen-activated protein kinase (MAPK) pathways in Alzheimer’s disease (AD). Mixed-lineage kinases (MLKs) regulate upstream MAPK signaling that include p38 MAPK and c-Jun amino-terminal kinase (JNK). However, whether MLK...

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Detalles Bibliográficos
Autores principales:	Dong, Weiguo, Embury, Christine M., Lu, Yaman, Whitmire, Sarah M., Dyavarshetty, Bhagyalaxmi, Gelbard, Harris A., Gendelman, Howard E., Kiyota, Tomomi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2016
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4940949/ https://www.ncbi.nlm.nih.gov/pubmed/27401058 http://dx.doi.org/10.1186/s12974-016-0646-z

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