Paclitaxel causes degeneration of both central and peripheral axon branches of dorsal root ganglia in mice

BACKGROUND: Peripheral neuropathy is a common and dose-limiting side effect of many cancer chemotherapies. The taxane agents, including paclitaxel (Taxol(®)), are effective chemotherapeutic drugs but cause degeneration of predominantly large myelinated afferent sensory fibers of the peripheral nervo...

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Detalles Bibliográficos
Autores principales: Tasnim, Aniqa, Rammelkamp, Zoe, Slusher, Amy B., Wozniak, Krystyna, Slusher, Barbara S., Farah, Mohamed H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4940970/
https://www.ncbi.nlm.nih.gov/pubmed/27401104
http://dx.doi.org/10.1186/s12868-016-0285-4

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