Update on ultrasensitive technologies to facilitate research on blood biomarkers for central nervous system disorders

Most research on fluid biomarkers for central nervous system (CNS) disorders has so far been performed using cerebrospinal fluid (CSF) as the biomarker source. CSF has the advantage of being closer to the brain than serum or plasma with a relative enrichment of CNS-specific proteins that are present...

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Detalles Bibliográficos
Autores principales: Andreasson, Ulf, Blennow, Kaj, Zetterberg, Henrik
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2016
Materias:
Blood Based Biomarkers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4941042/
https://www.ncbi.nlm.nih.gov/pubmed/27453931
http://dx.doi.org/10.1016/j.dadm.2016.05.005
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author Andreasson, Ulf
Blennow, Kaj
Zetterberg, Henrik
author_facet Andreasson, Ulf
Blennow, Kaj
Zetterberg, Henrik
author_sort Andreasson, Ulf
collection PubMed
description Most research on fluid biomarkers for central nervous system (CNS) disorders has so far been performed using cerebrospinal fluid (CSF) as the biomarker source. CSF has the advantage of being closer to the brain than serum or plasma with a relative enrichment of CNS-specific proteins that are present at very low concentrations in the blood and thus difficult to reliably quantify using standard immunochemical technologies. Recent technical breakthroughs in the field of ultrasensitive assays have started to change this. Here, we review the most established ultrasensitive quantitative technologies that are currently available to general biomarker laboratories and discuss their use in research on biomarkers for CNS disorders.
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spelling pubmed-49410422016-07-22 Update on ultrasensitive technologies to facilitate research on blood biomarkers for central nervous system disorders Andreasson, Ulf Blennow, Kaj Zetterberg, Henrik Alzheimers Dement (Amst) Blood Based Biomarkers Most research on fluid biomarkers for central nervous system (CNS) disorders has so far been performed using cerebrospinal fluid (CSF) as the biomarker source. CSF has the advantage of being closer to the brain than serum or plasma with a relative enrichment of CNS-specific proteins that are present at very low concentrations in the blood and thus difficult to reliably quantify using standard immunochemical technologies. Recent technical breakthroughs in the field of ultrasensitive assays have started to change this. Here, we review the most established ultrasensitive quantitative technologies that are currently available to general biomarker laboratories and discuss their use in research on biomarkers for CNS disorders. Elsevier 2016-06-25 /pmc/articles/PMC4941042/ /pubmed/27453931 http://dx.doi.org/10.1016/j.dadm.2016.05.005 Text en © 2016 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Blood Based Biomarkers
Andreasson, Ulf
Blennow, Kaj
Zetterberg, Henrik
Update on ultrasensitive technologies to facilitate research on blood biomarkers for central nervous system disorders
title Update on ultrasensitive technologies to facilitate research on blood biomarkers for central nervous system disorders
title_full Update on ultrasensitive technologies to facilitate research on blood biomarkers for central nervous system disorders
title_fullStr Update on ultrasensitive technologies to facilitate research on blood biomarkers for central nervous system disorders
title_full_unstemmed Update on ultrasensitive technologies to facilitate research on blood biomarkers for central nervous system disorders
title_short Update on ultrasensitive technologies to facilitate research on blood biomarkers for central nervous system disorders
title_sort update on ultrasensitive technologies to facilitate research on blood biomarkers for central nervous system disorders
topic Blood Based Biomarkers
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4941042/
https://www.ncbi.nlm.nih.gov/pubmed/27453931
http://dx.doi.org/10.1016/j.dadm.2016.05.005
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