Early-life stress leads to impaired spatial learning and memory in middle-aged ApoE4-TR mice

BACKGROUND: Apolipoprotein E (ApoE) is a major lipid carrier that supports lipid transport and injury repair in the brain. The APOE ε4 allele is associated with depression, mild cognitive impairment (MCI) and dementia; however, the precise molecular mechanism through which ApoE4 influences the risk...

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Detalles Bibliográficos
Autores principales: Lin, Lan-yan, Zhang, Jing, Dai, Xiao-man, Xiao, Nai-an, Wu, Xi-lin, Wei, Zhen, Fang, Wen-ting, Zhu, Yuan-gui, Chen, Xiao-chun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4941053/
https://www.ncbi.nlm.nih.gov/pubmed/27406263
http://dx.doi.org/10.1186/s13024-016-0107-2

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