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Automated brain volumetrics in multiple sclerosis: a step closer to clinical application
BACKGROUND: Whole brain volume (WBV) estimates in patients with multiple sclerosis (MS) correlate more robustly with clinical disability than traditional, lesion-based metrics. Numerous algorithms to measure WBV have been developed over the past two decades. We compare Structural Image Evaluation us...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BMJ Publishing Group
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4941129/ https://www.ncbi.nlm.nih.gov/pubmed/27071647 http://dx.doi.org/10.1136/jnnp-2015-312304 |
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author | Wang, C Beadnall, H N Hatton, S N Bader, G Tomic, D Silva, D G Barnett, M H |
author_facet | Wang, C Beadnall, H N Hatton, S N Bader, G Tomic, D Silva, D G Barnett, M H |
author_sort | Wang, C |
collection | PubMed |
description | BACKGROUND: Whole brain volume (WBV) estimates in patients with multiple sclerosis (MS) correlate more robustly with clinical disability than traditional, lesion-based metrics. Numerous algorithms to measure WBV have been developed over the past two decades. We compare Structural Image Evaluation using Normalisation of Atrophy-Cross-sectional (SIENAX) to NeuroQuant and MSmetrix, for assessment of cross-sectional WBV in patients with MS. METHODS: MRIs from 61 patients with relapsing-remitting MS and 2 patients with clinically isolated syndrome were analysed. WBV measurements were calculated using SIENAX, NeuroQuant and MSmetrix. Statistical agreement between the methods was evaluated using linear regression and Bland-Altman plots. Precision and accuracy of WBV measurement was calculated for (1) NeuroQuant versus SIENAX and (2) MSmetrix versus SIENAX. RESULTS: Precision (Pearson's r) of WBV estimation for NeuroQuant and MSmetrix versus SIENAX was 0.983 and 0.992, respectively. Accuracy (Cb) was 0.871 and 0.994, respectively. NeuroQuant and MSmetrix showed a 5.5% and 1.0% volume difference compared with SIENAX, respectively, that was consistent across low and high values. CONCLUSIONS: In the analysed population, NeuroQuant and MSmetrix both quantified cross-sectional WBV with comparable statistical agreement to SIENAX, a well-validated cross-sectional tool that has been used extensively in MS clinical studies. |
format | Online Article Text |
id | pubmed-4941129 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | BMJ Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-49411292016-07-13 Automated brain volumetrics in multiple sclerosis: a step closer to clinical application Wang, C Beadnall, H N Hatton, S N Bader, G Tomic, D Silva, D G Barnett, M H J Neurol Neurosurg Psychiatry Multiple Sclerosis BACKGROUND: Whole brain volume (WBV) estimates in patients with multiple sclerosis (MS) correlate more robustly with clinical disability than traditional, lesion-based metrics. Numerous algorithms to measure WBV have been developed over the past two decades. We compare Structural Image Evaluation using Normalisation of Atrophy-Cross-sectional (SIENAX) to NeuroQuant and MSmetrix, for assessment of cross-sectional WBV in patients with MS. METHODS: MRIs from 61 patients with relapsing-remitting MS and 2 patients with clinically isolated syndrome were analysed. WBV measurements were calculated using SIENAX, NeuroQuant and MSmetrix. Statistical agreement between the methods was evaluated using linear regression and Bland-Altman plots. Precision and accuracy of WBV measurement was calculated for (1) NeuroQuant versus SIENAX and (2) MSmetrix versus SIENAX. RESULTS: Precision (Pearson's r) of WBV estimation for NeuroQuant and MSmetrix versus SIENAX was 0.983 and 0.992, respectively. Accuracy (Cb) was 0.871 and 0.994, respectively. NeuroQuant and MSmetrix showed a 5.5% and 1.0% volume difference compared with SIENAX, respectively, that was consistent across low and high values. CONCLUSIONS: In the analysed population, NeuroQuant and MSmetrix both quantified cross-sectional WBV with comparable statistical agreement to SIENAX, a well-validated cross-sectional tool that has been used extensively in MS clinical studies. BMJ Publishing Group 2016-07 2016-04-12 /pmc/articles/PMC4941129/ /pubmed/27071647 http://dx.doi.org/10.1136/jnnp-2015-312304 Text en Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/ This is an Open Access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
spellingShingle | Multiple Sclerosis Wang, C Beadnall, H N Hatton, S N Bader, G Tomic, D Silva, D G Barnett, M H Automated brain volumetrics in multiple sclerosis: a step closer to clinical application |
title | Automated brain volumetrics in multiple sclerosis: a step closer to clinical application |
title_full | Automated brain volumetrics in multiple sclerosis: a step closer to clinical application |
title_fullStr | Automated brain volumetrics in multiple sclerosis: a step closer to clinical application |
title_full_unstemmed | Automated brain volumetrics in multiple sclerosis: a step closer to clinical application |
title_short | Automated brain volumetrics in multiple sclerosis: a step closer to clinical application |
title_sort | automated brain volumetrics in multiple sclerosis: a step closer to clinical application |
topic | Multiple Sclerosis |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4941129/ https://www.ncbi.nlm.nih.gov/pubmed/27071647 http://dx.doi.org/10.1136/jnnp-2015-312304 |
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