Meta-analysis of 49 549 individuals imputed with the 1000 Genomes Project reveals an exonic damaging variant in ANGPTL4 determining fasting TG levels

BACKGROUND: So far, more than 170 loci have been associated with circulating lipid levels through genome-wide association studies (GWAS). These associations are largely driven by common variants, their function is often not known, and many are likely to be markers for the causal variants. In this st...

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Autores principales: van Leeuwen, Elisabeth M, Sabo, Aniko, Bis, Joshua C, Huffman, Jennifer E, Manichaikul, Ani, Smith, Albert V, Feitosa, Mary F, Demissie, Serkalem, Joshi, Peter K, Duan, Qing, Marten, Jonathan, van Klinken, Jan B, Surakka, Ida, Nolte, Ilja M, Zhang, Weihua, Mbarek, Hamdi, Li-Gao, Ruifang, Trompet, Stella, Verweij, Niek, Evangelou, Evangelos, Lyytikäinen, Leo-Pekka, Tayo, Bamidele O, Deelen, Joris, van der Most, Peter J, van der Laan, Sander W, Arking, Dan E, Morrison, Alanna, Dehghan, Abbas, Franco, Oscar H, Hofman, Albert, Rivadeneira, Fernando, Sijbrands, Eric J, Uitterlinden, Andre G, Mychaleckyj, Josyf C, Campbell, Archie, Hocking, Lynne J, Padmanabhan, Sandosh, Brody, Jennifer A, Rice, Kenneth M, White, Charles C, Harris, Tamara, Isaacs, Aaron, Campbell, Harry, Lange, Leslie A, Rudan, Igor, Kolcic, Ivana, Navarro, Pau, Zemunik, Tatijana, Salomaa, Veikko, Kooner, Angad S, Kooner, Jaspal S, Lehne, Benjamin, Scott, William R, Tan, Sian-Tsung, de Geus, Eco J, Milaneschi, Yuri, Penninx, Brenda W J H, Willemsen, Gonneke, de Mutsert, Renée, Ford, Ian, Gansevoort, Ron T, Segura-Lepe, Marcelo P, Raitakari, Olli T, Viikari, Jorma S, Nikus, Kjell, Forrester, Terrence, McKenzie, Colin A, de Craen, Anton J M, de Ruijter, Hester M, Pasterkamp, Gerard, Snieder, Harold, Oldehinkel, Albertine J, Slagboom, P Eline, Cooper, Richard S, Kähönen, Mika, Lehtimäki, Terho, Elliott, Paul, van der Harst, Pim, Jukema, J Wouter, Mook-Kanamori, Dennis O, Boomsma, Dorret I, Chambers, John C, Swertz, Morris, Ripatti, Samuli, Willems van Dijk, Ko, Vitart, Veronique, Polasek, Ozren, Hayward, Caroline, Wilson, James G, Wilson, James F, Gudnason, Vilmundur, Rich, Stephen S, Psaty, Bruce M, Borecki, Ingrid B, Boerwinkle, Eric, Rotter, Jerome I, Cupples, L Adrienne, van Duijn, Cornelia M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2016
Materias:
Genome-Wide Studies
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4941146/
https://www.ncbi.nlm.nih.gov/pubmed/27036123
http://dx.doi.org/10.1136/jmedgenet-2015-103439

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