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Potential therapeutic implications of IL-6/IL-6R/gp130-targeting agents in breast cancer

Interleukin-6 (IL-6) is a pleiotropic cytokine with known multiple functions in immune regulation, inflammation, and oncogenesis. Binding of IL-6 to the IL-6 receptor (IL-6R) induces homodimerization and recruitment of glycoprotein 130 (gp130), which leads to activation of downstream signaling. Emer...

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Detalles Bibliográficos
Autores principales:	Heo, Tae-Hwe, Wahler, Joseph, Suh, Nanjoo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2016
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4941253/ https://www.ncbi.nlm.nih.gov/pubmed/26840088 http://dx.doi.org/10.18632/oncotarget.7102

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