Protective effect of α-lipoic acid against radiation-induced fibrosis in mice

Radiation-induced fibrosis (RIF) is one of the most common late complications of radiation therapy. We found that α-lipoic acid (α-LA) effectively prevents RIF. In RIF a mouse model, leg contracture assay was used to test the in vivo efficacy of α-LA. α-LA suppressed the expression of pro-fibrotic g...

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Detalles Bibliográficos
Autores principales: Ryu, Seung-Hee, Park, Eun-Young, Kwak, Sungmin, Heo, Seung-Ho, Ryu, Je-Won, Park, Jin-hong, Choi, Kyung-Chul, Lee, Sang-wook
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4941260/
https://www.ncbi.nlm.nih.gov/pubmed/26799284
http://dx.doi.org/10.18632/oncotarget.6952
Descripción
Sumario:Radiation-induced fibrosis (RIF) is one of the most common late complications of radiation therapy. We found that α-lipoic acid (α-LA) effectively prevents RIF. In RIF a mouse model, leg contracture assay was used to test the in vivo efficacy of α-LA. α-LA suppressed the expression of pro-fibrotic genes after irradiation, both in vivo and in vitro, and inhibited the up-regulation of TGF-β1-mediated p300/CBP activity. Thus, α-LA prevents radiation-induced fibrosis (RIF) by inhibiting the transcriptional activity of NF-κB through inhibition of histone acetyltransferase activity. α-LA is a new therapeutic methods that can be used in the prevention-treatment of RIF.

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