SI113, a SGK1 inhibitor, potentiates the effects of radiotherapy, modulates the response to oxidative stress and induces cytotoxic autophagy in human glioblastoma multiforme cells

Glioblastoma multiforme (GBM) is the most aggressive CNS tumor and is characterized by a very high frequency of clinical relapse after therapy and thus by a dismal prognosis, which strongly compromises patients survival. We have recently identified the small molecule SI113, as a potent and selective...

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Detalles Bibliográficos
Autores principales: Talarico, Cristina, Dattilo, Vincenzo, D'Antona, Lucia, Barone, Agnese, Amodio, Nicola, Belviso, Stefania, Musumeci, Francesca, Abbruzzese, Claudia, Bianco, Cataldo, Trapasso, Francesco, Schenone, Silvia, Alcaro, Stefano, Ortuso, Francesco, Florio, Tullio, Paggi, Marco G., Perrotti, Nicola, Amato, Rosario
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4941283/
https://www.ncbi.nlm.nih.gov/pubmed/26908461
http://dx.doi.org/10.18632/oncotarget.7520

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4941283/
https://www.ncbi.nlm.nih.gov/pubmed/26908461
http://dx.doi.org/10.18632/oncotarget.7520

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