Genetic variant rs4072037 of MUC1 and gastric cancer risk in an Eastern Chinese population

Published data on the association between the MUC1 rs4072037A > G polymorphism and gastric cancer (GCa) risk were inconclusive. To derive a more precise estimation of the association, we conducted a large GCa study of 1,124 cases and 1,192 controls to confirm this association in an Eastern Chines...

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Detalles Bibliográficos
Autores principales: Qiu, Li-Xin, Hua, Rui-Xi, Cheng, Lei, He, Jing, Wang, Meng-Yun, Zhou, Fei, Zhu, Xiao-Dong, Sun, Meng-Hong, Zhou, Xiao-Yan, Li, Jin, Wang, Ya-Nong, Yang, Ya-Jun, Wang, Jiu-Cun, Jin, Li, Guo, Wei-Jian, Wei, Qing-Yi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4941287/
https://www.ncbi.nlm.nih.gov/pubmed/26910281
http://dx.doi.org/10.18632/oncotarget.7527
Descripción
Sumario:Published data on the association between the MUC1 rs4072037A > G polymorphism and gastric cancer (GCa) risk were inconclusive. To derive a more precise estimation of the association, we conducted a large GCa study of 1,124 cases and 1,192 controls to confirm this association in an Eastern Chinese population. Our results showed that the G allele was strongly associated with a decreased GCa risk in the study population [GG vs. AA, odds ratio (OR) = 0.47, 95% confidence interval (CI) = 0.31–0.73; AG/GG vs. AA, OR = 0.82, 95% CI = 0.68–0.99; GG vs. AA/AG, OR = 0.48, 95% CI = 0.32–0.74]. These associations remained significant in subgroups of age, tumor site, drinking and smoking status. Moreover, this association was supported by an additional meta-analysis of published studies. In summary, these results suggest that the MUC1 rs4072037G allele may be a low-penetrating protection factor for GCa risk in Chinese populations.

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