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Prognostic significance and optimal cutoff of age in medullary thyroid cancer
Age has been found to correlate with the prognosis for medullary thyroid cancer (MTC). This study was conducted to investigate whether age can predict long-term unfavorable prognosis and evaluate its predictive accuracy associated with TNM staging, using data of patients diagnosed with MTC between 2...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals LLC
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4941288/ https://www.ncbi.nlm.nih.gov/pubmed/26910117 http://dx.doi.org/10.18632/oncotarget.7556 |
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author | Qu, Ning Shi, Rong-liang Luo, Ting-xian Wang, Yu-long Li, Duan-shu Wang, Yu Huang, Cai-ping Ji, Qing-hai |
author_facet | Qu, Ning Shi, Rong-liang Luo, Ting-xian Wang, Yu-long Li, Duan-shu Wang, Yu Huang, Cai-ping Ji, Qing-hai |
author_sort | Qu, Ning |
collection | PubMed |
description | Age has been found to correlate with the prognosis for medullary thyroid cancer (MTC). This study was conducted to investigate whether age can predict long-term unfavorable prognosis and evaluate its predictive accuracy associated with TNM staging, using data of patients diagnosed with MTC between 2000 and 2010 from Surveillance, Epidemiology and End Results database. The relationship between the patients’ age at diagnosis and cancer-specific survival (CSS) was evaluated using multivariate Cox regression analysis. Age stratifications were combined into a nomogram model to predict the CSS of MTC. The X-tile program determined 49 and 69 as optimal age cutoff values for CSS. On multivariate analysis, independent factors for survival were age (50–69 years, HR 2.853, 95% CI 1.631–4.991; ≥70 years, HR 5.804, 95% CI 2.91–11.555), race (white, HR 0.344, 95% CI 0.188–0.630), T (T3/4, HR 3.931, 95% CI 2.093–7.381), N (N1a, HR 3.269, 95% CI 1.386–7.710) and M (M1, HR 3.998, 95% CI 2.419–6.606). The C-index for CSS prediction with TNM, age (cutoff of 45)/sex/race/TNM and age (cutoff of 49 and 69)/sex/race/TNM were 0.832 (95% CI 0.763–0.901), 0.863 (95% CI 0.799–0.928), and 0.876 (95% CI 0.817–0.935), respectively. Subgroup multivariate analyses also showed that age significantly increased the risk for CSS in females, non-Hispanic white patients, and those with stage IV MTC. In conclusion, CSS was independently associated with ages between 49 and 69 years, which might be applied for risk stratification in MTC patients. |
format | Online Article Text |
id | pubmed-4941288 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Impact Journals LLC |
record_format | MEDLINE/PubMed |
spelling | pubmed-49412882016-07-19 Prognostic significance and optimal cutoff of age in medullary thyroid cancer Qu, Ning Shi, Rong-liang Luo, Ting-xian Wang, Yu-long Li, Duan-shu Wang, Yu Huang, Cai-ping Ji, Qing-hai Oncotarget Research Paper Age has been found to correlate with the prognosis for medullary thyroid cancer (MTC). This study was conducted to investigate whether age can predict long-term unfavorable prognosis and evaluate its predictive accuracy associated with TNM staging, using data of patients diagnosed with MTC between 2000 and 2010 from Surveillance, Epidemiology and End Results database. The relationship between the patients’ age at diagnosis and cancer-specific survival (CSS) was evaluated using multivariate Cox regression analysis. Age stratifications were combined into a nomogram model to predict the CSS of MTC. The X-tile program determined 49 and 69 as optimal age cutoff values for CSS. On multivariate analysis, independent factors for survival were age (50–69 years, HR 2.853, 95% CI 1.631–4.991; ≥70 years, HR 5.804, 95% CI 2.91–11.555), race (white, HR 0.344, 95% CI 0.188–0.630), T (T3/4, HR 3.931, 95% CI 2.093–7.381), N (N1a, HR 3.269, 95% CI 1.386–7.710) and M (M1, HR 3.998, 95% CI 2.419–6.606). The C-index for CSS prediction with TNM, age (cutoff of 45)/sex/race/TNM and age (cutoff of 49 and 69)/sex/race/TNM were 0.832 (95% CI 0.763–0.901), 0.863 (95% CI 0.799–0.928), and 0.876 (95% CI 0.817–0.935), respectively. Subgroup multivariate analyses also showed that age significantly increased the risk for CSS in females, non-Hispanic white patients, and those with stage IV MTC. In conclusion, CSS was independently associated with ages between 49 and 69 years, which might be applied for risk stratification in MTC patients. Impact Journals LLC 2016-02-21 /pmc/articles/PMC4941288/ /pubmed/26910117 http://dx.doi.org/10.18632/oncotarget.7556 Text en Copyright: © 2016 Qu et al. http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Paper Qu, Ning Shi, Rong-liang Luo, Ting-xian Wang, Yu-long Li, Duan-shu Wang, Yu Huang, Cai-ping Ji, Qing-hai Prognostic significance and optimal cutoff of age in medullary thyroid cancer |
title | Prognostic significance and optimal cutoff of age in medullary thyroid cancer |
title_full | Prognostic significance and optimal cutoff of age in medullary thyroid cancer |
title_fullStr | Prognostic significance and optimal cutoff of age in medullary thyroid cancer |
title_full_unstemmed | Prognostic significance and optimal cutoff of age in medullary thyroid cancer |
title_short | Prognostic significance and optimal cutoff of age in medullary thyroid cancer |
title_sort | prognostic significance and optimal cutoff of age in medullary thyroid cancer |
topic | Research Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4941288/ https://www.ncbi.nlm.nih.gov/pubmed/26910117 http://dx.doi.org/10.18632/oncotarget.7556 |
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