IL-15 superagonist/IL-15RαSushi-Fc fusion complex (IL-15SA/IL-15RαSu-Fc; ALT-803) markedly enhances specific subpopulations of NK and memory CD8+ T cells, and mediates potent anti-tumor activity against murine breast and colon carcinomas

Interleukin (IL)-15-N72D superagonist-complexed with IL-15RαSushi-Fc fusion protein (IL-15SA/IL-15RαSu-Fc; ALT-803) has been reported to exhibit significant anti-tumor activity in murine myeloma, rat bladder cancer, and murine glioblastoma models. In this study, we examined the immunomodulatory and...

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Detalles Bibliográficos
Autores principales: Kim, Peter S., Kwilas, Anna R., Xu, Wenxin, Alter, Sarah, Jeng, Emily K., Wong, Hing C., Schlom, Jeffrey, Hodge, James W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4941302/
https://www.ncbi.nlm.nih.gov/pubmed/26910920
http://dx.doi.org/10.18632/oncotarget.7470

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4941302/
https://www.ncbi.nlm.nih.gov/pubmed/26910920
http://dx.doi.org/10.18632/oncotarget.7470

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