A small molecule induces integrin β4 nuclear translocation and apoptosis selectively in cancer cells with high expression of integrin β4

Increased integrin β4 (ITGB4) level is accompanied by malignant progression of multiple carcinomas. However, selective therapeutic strategies against cancer cells expressing a high level of ITGB4 have not been reported. Here, for the first time, we report that a chiral small molecule, SEC, selective...

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Detalles Bibliográficos
Autores principales: Liu, ShuYan, Ge, Di, Chen, LiNa, Zhao, Jing, Su, Le, Zhang, ShangLi, Miao, JunYing, Zhao, BaoXiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4941314/
https://www.ncbi.nlm.nih.gov/pubmed/26918348
http://dx.doi.org/10.18632/oncotarget.7646

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