VEGFR2 targeted antibody fused with MICA stimulates NKG2D mediated immunosurveillance and exhibits potent anti-tumor activity against breast cancer

Binding of MHC class I-related chain molecules A and B (MICA/B) to the natural killer (NK) cell receptor NK group 2, member D (NKG2D) is thought critical for activating NK-mediated immunosurveillance. Angiogenesis is important for tumor growth and interfering with angiogenesis using the fully human...

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Detalles Bibliográficos
Autores principales: Wei, Xie, Liu, Fang, Wang, Youfu, Ren, Xueyan, Wang, Tong, Chen, Zhiguo, Tang, Mingying, Sun, Fumou, Li, Zhaoting, Wang, Min, Zhang, Juan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4941327/
https://www.ncbi.nlm.nih.gov/pubmed/26909862
http://dx.doi.org/10.18632/oncotarget.7501

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